Enzyme Details

EC Classification

1.14.11.2

Enzyme name
(recommended)

procollagen-proline dioxygenase

Alternative names

procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
protocollagen hydroxylase
proline hydroxylase
proline,2-oxoglutarate 4-dioxygenase
collagen proline hydroxylase
hydroxylase, collagen proline
peptidyl proline hydroxylase
proline protocollagen hydroxylase
proline, 2-oxoglutarate dioxygenase
prolyl hydroxylase
prolylprotocollagen dioxygenase
prolylprotocollagen hydroxylase
protocollagen proline 4-hydroxylase
protocollagen proline dioxygenase
protocollagen proline hydroxylase
protocollagen prolyl hydroxylase
prolyl 4-hydroxylase
prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating
procollagen-proline 4-dioxygenase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Catalyses reactions

O2 + 2-Oxoglutarate + (Pro-Pro-Gly)5 <-> CO2 + Succinate + (Pro-4-hydroxy-Pro-Gly)5

O2 + 2-Oxoglutarate + Procollagen L-proline <-> CO2 + Succinate + Procollagen trans-4-hydroxy-L-proline

L-Proline + O2 + 2-Oxoglutarate <-> CO2 + Succinate + trans-4-Hydroxy-L-proline

O2 + 2-Oxoglutarate + (Pro-Pro-Gly)10 <-> CO2 + Succinate + (Pro-4-hydroxy-Pro-Gly)10

O2 + 2-Oxoglutarate + Polyproline <-> CO2 + Succinate + 4-Hydroxyprolyl-peptide

O2 + 2-Oxoglutarate + (Ala-Thr-Pro-Pro-Pro-Val)3 <-> CO2 + Succinate + 4-Hydroxyprolyl-peptide

O2 + 2-Oxoglutarate + Ser-Pro-Pro-Pro-Pro-Val-Ser-Pro-Pro-Pro-Val-Ser-Pro-Pro-Pro-Pro-Val <-> CO2 + Succinate + 4-Hydroxyprolyl-peptide