Pathway Details

Recommended name

Cysteine and methionine metabolism

Alternative names

Reactions

NAD+ + (2R)-3-Sulfolactate <-> NADH + H+ + 3-Sulfopyruvate

Hydrogen sulfide + O-Phospho-L-serine <-> Phosphate + L-Cysteine

Sulfate + L-Cystine <-> L-Cysteine + S-Sulfo-L-cysteine

H2O + L-Methionine + Oxidized thioredoxin <-> Reduced thioredoxin + L-Methionine S-oxide

Hydrogen sulfide + O-Acetyl-L-homoserine <-> Acetate + L-Homocysteine

L-Cysteine + Sulfite <-> Hydrogen sulfide + L-Cysteate

ATP + L-Methionine + tRNA(Met) <-> Diphosphate + AMP + L-Methionyl-tRNA(Met)

H2O + S-Ribosyl-L-homocysteine <-> D-Ribose + L-Homocysteine

O2 + 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one <-> Formate + 4-Methylthio-2-oxobutanoate

H2O + L-Methionine <-> NH3 + 2-Oxobutyrate + Methanethiol

L-Glutamate + 4-Methylthio-2-oxobutanoate <-> L-Methionine + 2-Oxoglutarate

O-Acetyl-L-serine + Thiosulfate <-> Acetate + S-Sulfo-L-cysteine

L-Serine <-> H2O + 2-Aminoacrylate

H2O + Aminoacyl-L-methionine <-> L-Methionine

H2O + 1-Aminocyclopropane-1-carboxylate <-> NH3 + 2-Oxobutyrate

L-Homocysteine + 5-Methyltetrahydropteroyltri-L-glutamate <-> L-Methionine + Tetrahydropteroyltri-L-glutamate

Sulfate + S-Glutathionyl-L-cysteine <-> Reduced glutathione + S-Sulfo-L-cysteine

S-Adenosyl-L-methionine <-> 5'-Deoxy-5'-(methylthio)adenosine + 1-Aminocyclopropane-1-carboxylate

H2O + S-Adenosyl-L-homocysteine <-> Adenosine + L-Homocysteine

L-Cysteine + 2-Oxoglutarate <-> L-Glutamate + 3-Mercaptopyruvate

Phosphate + 5'-Deoxy-5'-(methylthio)adenosine <-> Adenine + 5-Methylthio-D-ribose 1-phosphate

2-Oxoglutarate + O-Phospho-L-serine <-> L-Glutamate + 3-Phosphohydroxypyruvate

H2O + L-Cystathionine <-> Pyruvate + NH3 + L-Homocysteine

S-Adenosyl-L-methionine + L-Homocysteine <-> L-Methionine + S-Adenosyl-L-homocysteine

H+ + Reduced thioredoxin + O-Acetyl-L-homoserine + Thiosulfate <-> Acetate + Oxidized thioredoxin + L-Homocysteine + Sulfite

2 Reduced glutathione + Homocystine <-> Oxidized glutathione + 2 L-Homocysteine

Putrescine + S-Adenosylmethioninamine <-> 5'-Deoxy-5'-(methylthio)adenosine + Spermidine

ATP + L-Cysteine + tRNA(Cys) <-> Diphosphate + AMP + L-Cysteinyl-tRNA(Cys)

NADP+ + L-Homoserine <-> H+ + NADPH + L-Aspartate 4-semialdehyde

2,3-Diketo-5-methylthiopentyl-1-phosphate <-> 2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

Adenosine + Homocysteine <-> H2O + S-Adenosyl-L-homocysteine

ATP + L-Aspartate <-> ADP + 4-Phospho-L-aspartate

Succinyl-CoA + L-Homoserine <-> Coenzyme A + O-Succinyl-L-homoserine

L-Cysteine + 2-Oxoglutarate <-> Glutamate + 3-Mercaptopyruvate

Acetyl-CoA + L-Homoserine <-> Coenzyme A + O-Acetyl-L-homoserine

Phosphate + Diphosphate + S-Adenosyl-L-methionine <-> ATP + H2O + L-Methionine

O-Succinyl-L-homoserine <-> Pyruvate + NH3 + Succinate

Hydrogen sulfide + O-Acetyl-L-serine <-> L-Cysteine + Acetate

L-Cysteine + NADP+ + Reduced glutathione <-> H+ + NADPH + S-Glutathionyl-L-cysteine

H2O + N-Formyl-L-methionine <-> L-Methionine + Formate

NAD+ + 3-Mercaptolactate <-> NADH + H+ + 3-Mercaptopyruvate

H2O + L-Methionine + O2 <-> NH3 + H2O2 + 4-Methylthio-2-oxobutanoate

H2O + S-Adenosyl-L-homocysteine <-> Adenine + S-Ribosyl-L-homocysteine

L-Cysteine + 2 O-Succinyl-L-homoserine <-> Pyruvate + NH3 + 2 Succinate + L-Cystathionine

10-Formyltetrahydrofolate + L-Methionyl-tRNA(Met) <-> 5,6,7,8-Tetrahydrofolate + N-Formylmethionyl-tRNA(fMet)

H2O + 5'-Deoxy-5'-(methylthio)adenosine <-> Adenine + 5-Methylthio-D-ribose

H2O + D-Cysteine <-> Pyruvate + NH3 + Hydrogen sulfide

S-Ribosyl-L-homocysteine <-> Homocysteine + 4,5-Dihydroxy-2,3-pentanedione

H2O + L-Cysteine <-> Pyruvate + NH3 + Hydrogen sulfide

H2O + L-Cystine <-> Pyruvate + NH3 + Thiocysteine

Phosphate + NADP+ + L-Aspartate 4-semialdehyde <-> H+ + NADPH + 4-Phospho-L-aspartate

H2O + O-Succinyl-L-homoserine <-> NH3 + Succinate + 2-Oxobutyrate

S-Adenosyl-L-methionine <-> CO2 + S-Adenosylmethioninamine

3-Mercaptopyruvate + Sulfite <-> Pyruvate + H2S2O3

L-Serine + Acetyl-CoA <-> Coenzyme A + O-Acetyl-L-serine

H2O + 2,3-Diketo-5-methylthiopentyl-1-phosphate <-> Phosphate + 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

L-Cysteine <-> D-Cysteine

O-Succinyl-L-homoserine + Sulfide <-> Succinate + L-Homocysteine

L-Cysteine + O2 <-> 3-Sulfino-L-alanine

NAD+ + 3-Phospho-D-glycerate <-> NADH + H+ + 3-Phosphohydroxypyruvate

ATP + 5-Methylthio-D-ribose <-> ADP + 5-Methylthio-D-ribose 1-phosphate

O-Acetyl-L-homoserine + Methanethiol <-> L-Methionine + Acetate

3 S-Adenosyl-L-methionine <-> 3 5'-Deoxy-5'-(methylthio)adenosine + Nicotianamine

L-Glutamine + 4-Methylthio-2-oxobutanoate <-> L-Methionine + 2-Oxoglutaramate

L-Homocysteine + 5-Methyltetrahydrofolate <-> L-Methionine + 5,6,7,8-Tetrahydrofolate

L-Cysteine + O-Acetyl-L-homoserine <-> Acetate + L-Cystathionine

L-Cysteine + O-Succinyl-L-homoserine <-> Succinate + L-Cystathionine

Glycerate 3-phosphate + NAD+ <-> NADH + H+ + 3-Phosphohydroxypyruvate

3-Sulfino-L-alanine <-> L-Alanine + SO2

H2O + 2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate <-> Phosphate + 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

2-Oxoglutarate + 3-Sulfino-L-alanine <-> Glutamate + 3-Sulfinylpyruvate

2 Reduced glutathione + L-Cystine <-> 2 L-Cysteine + Oxidized glutathione

NADP+ + (2R)-3-Sulfolactate <-> H+ + NADPH + 3-Sulfopyruvate

NAD+ + (S)-3-Sulfolactate <-> NADH + H+ + 3-Sulfopyruvate

L-Homocysteine + Betaine <-> L-Methionine + N,N-Dimethylglycine

NAD+ + L-Homoserine <-> NADH + H+ + L-Aspartate 4-semialdehyde

Spermidine + S-Adenosylmethioninamine <-> 5'-Deoxy-5'-(methylthio)adenosine + Spermine

3'-Phosphoadenylyl sulfate + 2-Aminoacrylate <-> Adenosine 3',5'-bisphosphate + L-Cysteate

3-Sulfinylpyruvate <-> Pyruvate + SO2

NAD+ + 2 L-Cysteine <-> NADH + H+ + L-Cystine

O-Acetyl-L-serine + Sulfide <-> L-Cysteine + Acetate

H2O + L-Cystathionine <-> L-Cysteine + NH3 + 2-Oxobutyrate

2-Oxoglutarate + L-Cysteate <-> Glutamate + 3-Sulfopyruvate

O2 + 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one <-> Formate + Carbon monoxide + 3-(Methylthio)propionic acid

O2 + L-Ascorbate + 1-Aminocyclopropane-1-carboxylate <-> 2 H2O + CO2 + Cyanide + Ethylene + Dehydroascorbate

S-Adenosyl-L-methionine + Cytosine (in DNA) <-> S-Adenosyl-L-homocysteine + 5-Methylcytosine (in DNA)

H+ + Reduced thioredoxin + O-Acetyl-L-serine + Thiosulfate <-> L-Cysteine + Acetate + Oxidized thioredoxin + Sulfite

NAD+ + H2O + 3-Sulfino-L-alanine <-> NADH + H+ + NH3 + 3-Sulfinylpyruvate

L-Serine + L-Homocysteine <-> H2O + L-Cystathionine

Classification

Amino Acid Metabolism