Pathway Details

Recommended name

Glutathione metabolism

Alternative names

Reactions

NADP+ + beta-D-Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone

NADP+ + 6-Phospho-D-gluconate <-> H+ + NADPH + CO2 + D-Ribulose 5-phosphate

NADP+ + Isocitrate <-> H+ + NADPH + CO2 + 2-Oxoglutarate

H2O2 + 2 Reduced glutathione <-> 2 H2O + Oxidized glutathione

NADP+ + 6-Phospho-D-gluconate <-> H+ + NADPH + 6-Phospho-2-dehydro-D-gluconate

NADP+ + 2 Reduced glutathione <-> H+ + NADPH + Oxidized glutathione

O2 + 2 Reduced glutathione <-> H2O2 + Oxidized glutathione

ATP + 2 H2O + 5-Oxoproline <-> ADP + Phosphate + L-Glutamate

H2O + Reduced glutathione <-> L-Glutamate + L-Cysteinylglycine

ATP + Glycine + gamma-L-Glutamyl-L-cysteine <-> ADP + Phosphate + Reduced glutathione

L-Ascorbate + H2O2 <-> 2 H2O + Dehydroascorbate

L-Ascorbate + H2O2 <-> 2 H2O + L-Dehydroascorbate

L-Ornithine <-> CO2 + Putrescine

ATP + L-Glutamate + L-Cysteine <-> ADP + Phosphate + gamma-L-Glutamyl-L-cysteine

H2O + L-Cysteinylglycine <-> Glycine + L-Cysteine

2 Reduced glutathione + L-Dehydroascorbate <-> L-Ascorbate + Oxidized glutathione

2 Reduced glutathione + Cystine <-> Oxidized glutathione + 2 Cysteine

2 Reduced glutathione + Homocystine <-> Oxidized glutathione + 2 Homocysteine

Coenzyme A + Oxidized glutathione <-> Reduced glutathione + CoA-glutathione

2 Reduced glutathione + Dehydroascorbate <-> L-Ascorbate + Oxidized glutathione

Reduced glutathione + L-Amino acid <-> L-Cysteinylglycine + (5-L-Glutamyl)-L-amino acid

2 Reduced glutathione + Thiosulfate <-> Oxidized glutathione + Sulfide + Sulfite

ATP + Reduced glutathione + Spermidine <-> ADP + Phosphate + Glutathionylspermidine

H2O + Glutathionylspermidine <-> Reduced glutathione + Spermidine

Putrescine + S-Adenosylmethioninamine <-> 5'-Deoxy-5'-(methylthio)adenosine + Spermidine

NADP+ + 2 gamma-L-Glutamyl-L-cysteine <-> H+ + NADPH + Bis-gamma-glutamylcystine

gamma-L-Glutamyl-L-cysteine <-> L-Cysteine + 5-Oxoproline

Spermidine + S-Adenosylmethioninamine <-> 5'-Deoxy-5'-(methylthio)adenosine + Spermine

2 Reduced glutathione + Lipid hydroperoxide <-> 2 H2O + Oxidized glutathione + Lipid

Reduced glutathione + RX <-> HX + R-S-Glutathione

(5-L-Glutamyl)-L-amino acid <-> L-Amino acid + 5-Oxoproline

NADP+ + Reduced trypanothione <-> H+ + NADPH + Oxidized trypanothione

ATP + Reduced glutathione + Glutathionylspermidine <-> ADP + Phosphate + Reduced trypanothione

Oxidized glutathione + Protein dithiol <-> 2 Reduced glutathione + Protein disulfide

H2O + R-S-Glutathione <-> L-Glutamate + R-S-Alanylglycine

Oxidized glutathione + Pyrimidodiazepine <-> 2 Reduced glutathione + 6-Pyruvoyltetrahydropterin

Oxidized glutathione + [Xanthine dehydrogenase] <-> Reduced glutathione + [Xanthine oxidase]

Acetyl-CoA + L-cysteine-S-conjugate <-> Coenzyme A + S-Substituted N-acetyl-L-cysteine

Acetyl-CoA + R-S-Alanine <-> Coenzyme A + Mercapturonate

Glycine + R-S-Alanine <-> R-S-Alanylglycine

Reduced glutathione + 1-Fluoro-2,4-dinitrobenzene <-> S-(2,4-Dinitrophenyl)glutathione + HF

Reduced glutathione + 1-Chloro-2,4-dinitrobenzene <-> HCl + S-(2,4-Dinitrophenyl)glutathione

H2O + L-alpha-Methyl-gamma-glutamyl-L-alpha-aminobutyrate <-> L-alpha-Aminobutyrate + L-alpha-Methyl glutamate

L-Methionine + L-alpha-Methyl-gamma-glutamyl-L-alpha-aminobutyrate <-> L-alpha-Aminobutyrate + L-alpha-Methyl-gamma-glutamylmethionine

ATP + 2 H2O + 5-Oxo-L-proline <-> ADP + Phosphate + L-Glutamate

Cadaverine + S-Adenosylmethioninamine <-> 5'-Deoxy-5'-(methylthio)adenosine + Aminopropylcadaverine

Reduced glutathione <-> L-Cysteinylglycine + 5-Oxoproline

Classification

Metabolism of Other Amino Acids