Enzyme Details

 EC Classification 1.1.1.1
 Enzyme name
(recommended)
alcohol dehydrogenase
 Alternative names alcohol:NAD+ oxidoreductase
aldehyde reductase
ADH
alcohol dehydrogenase (NAD)
aliphatic alcohol dehydrogenase
ethanol dehydrogenase
NAD-dependent alcohol dehydrogenase
NAD-specific aromatic alcohol dehydrogenase
NADH-alcohol dehydrogenase
NADH-aldehyde dehydrogenase
primary alcohol dehydrogenase
yeast alcohol dehydrogenase
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
Ethanol + NADP+ <-> H+ + NADPH + Acetaldehyde
NADP+ + 1,2-Propanediol <-> H+ + NADPH + Lactaldehyde
NAD+ + Ethanol <-> NADH + H+ + Acetaldehyde
NAD+ + Methanol <-> NADH + H+ + Formaldehyde
NAD+ + Primary alcohol <-> NADH + H+ + Aldehyde
NAD+ + Secondary alcohol <-> NADH + H+ + Ketone
NAD+ + Glycerol <-> NADH + H+ + D-Glyceraldehyde
NADP+ + Glycerol <-> H+ + NADPH + Dihydroxyacetone
NAD+ + H2O + Benzaldehyde <-> NADH + H+ + Benzoate
H+ + NADPH + Acetone <-> NADP+ + 2-Propanol
NAD+ + Benzyl alcohol <-> NADH + H+ + Benzaldehyde
NAD+ + Glycol <-> NADH + H+ + Glycolaldehyde
NAD+ + Retinol <-> NADH + H+ + all-trans-Retinal
NAD+ + 1-Propanol <-> NADH + H+ + Propanal
H+ + NADPH + Methylglyoxal <-> NADP+ + Hydroxyacetone
NAD+ + Phenylethyl alcohol <-> NADH + H+ + Phenylacetaldehyde
NAD+ + Indole-3-ethanol <-> NADH + H+ + Indole-3-acetaldehyde
NAD+ + 1-Octanol <-> NADH + H+ + 1-Octanal
NAD+ + 11-cis-Retinol <-> NADH + H+ + 11-cis-Retinal
NAD+ + 3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane <-> NADH + H+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al
NADH + H+ + Butanal <-> NAD+ + 1-Butanol
H+ + NADPH + Butanal <-> NADP+ + 1-Butanol
NAD+ + 3alpha,7alpha,26-Trihydroxy-5beta-cholestane <-> NADH + H+ + 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al
NAD+ + 3,4-Dihydroxyphenylethyleneglycol <-> NADH + H+ + 3,4-Dihydroxymandelaldehyde
NAD+ + 3-Methylbutanol <-> NADH + H+ + 3-Methylbutanal
NAD+ + H2O + Butanal <-> NADH + H+ + Butanoate
H+ + NADPH + Glyceraldehyde <-> NADP+ + Glycerol
H+ + NADPH + Glycolaldehyde <-> NADP+ + Glycol
H+ + NADPH + Propanal <-> NADP+ + 1-Propanol
H2O + NADP+ + Propanal <-> H+ + NADPH + Propanoate
NAD+ + 12-Hydroxydodecanoic acid <-> NADH + H+ + 12-Oxododecanoic acid
NAD+ + 1-Pentanol <-> NADH + H+ + 1-Pentanal
NAD+ + S-(Hydroxymethyl)glutathione <-> NADH + H+ + S-Formylglutathione
NAD+ + 2-Buten-1-ol <-> NADH + H+ + 2-Butenal
NADH + H+ + m-Nitrobenzaldehyde <-> NAD+ + m-Nitrobenzyl alcohol
NAD+ + 1-Hexanol <-> NADH + H+ + Hexanal
NAD+ + (S)-2-Butanol <-> NADH + H+ + 2-Butanone
NADH + H+ + 2-Butanone <-> NAD+ + 2-Butanol
NADP+ + (S)-2-Butanol <-> H+ + NADPH + 2-Butanone
H+ + NADPH + 2-Butanone <-> NADP+ + 2-Butanol
NADH + H+ + Acetone <-> NAD+ + 2-Propanol
NAD+ + 13-cis-Retinol <-> NADH + H+ + 13-cis-Retinal
NAD+ + 7-cis-Retinol <-> NADH + H+ + 7-cis-Retinal
NADH + H+ + 9-cis-Retinal <-> NAD+ + 9-cis-Retinol
NAD+ + Methylcrotyl alcohol <-> NADH + H+ + Methylcrotyl aldehyde
NAD+ + (R)-2-Butanol <-> NADH + H+ + 2-Butanone
H2O + p-Nitrophenyl acetate <-> Acetate + p-Nitrophenol
NADH + H+ + 3-Methylcyclohexanone <-> NAD+ + 3-Methylcyclohexanol
NADH + H+ + p-Anisaldehyde <-> NAD+ + 4-Methoxybenzyl alcohol
NADH + H+ + Cyclopetanone <-> NAD+ + Cyclopentanol
NADH + H+ + 3-Methylbutan-2-one <-> NAD+ + 3-Methylbutan-2-ol
NAD+ + Pentan-3-ol <-> NADH + H+ + 3-Pentanone
NAD+ + 2-Pentanol <-> NADH + H+ + 2-Pentanone
NADP+ + S-(Hydroxymethyl)glutathione <-> H+ + NADPH + S-Formylglutathione
NAD+ + Cyclohexanol <-> NADH + H+ + Cyclohexanone
NADH + H+ + 4-Oxoretinal <-> NAD+ + 4-Oxoretinol
NAD+ + 2-Deoxy-D-ribose <-> Unknown + NADH + H+
NADH + H+ + all-trans-Dehydroretinal <-> NAD+ + 3,4-Didehydroretinol
NAD+ + 4-Hydroxyretinol <-> NADH + H+ + 4-Hydroxyretinal
H+ + NADPH + Acetoin <-> NADP+ + 2,3-Butanediol
NAD+ + 16-Hydroxyhexadecanoic acid <-> NADH + H+ + 16-Oxohexadecanoic acid
NAD+ + 4-Hydroxy-3-methoxy-benzenemethanol <-> NADH + H+ + 4-Hydroxy-3-methoxy-benzaldehyde
NAD+ + 3-Phenyl-1-propanol <-> NADH + H+ + 3-Phenyl-1-propanone
NAD+ + Isobutanol <-> NADH + H+ + 2-Methylpropanal
NADH + H+ + 20-CHO-Leukotriene B4 <-> NAD+ + 20-OH-Leukotriene B4
NAD+ + 5beta-Androstane-3beta-ol-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
NADH + H+ + 5beta-Androstane-17beta-ol-3-one <-> NAD+ + 5beta-Androstane-3beta,17beta-diol
NADH + H+ + 3-Oxo-5beta-cholanate <-> NAD+ + 3beta-Hydroxy-5beta-cholanate
NAD+ + 3beta-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione
NAD+ + 3beta-Hydroxy-5alpha-pregnane-20-one <-> NADH + H+ + 5alpha-Pregnane-3,20-dione
NADH + H+ + 2-Methylbutanal <-> NAD+ + 2-Methylbutanol
Pyruvate + H+ + NADPH <-> NADP+ + L-Lactate
H+ + NADPH + Hydroxyacetone <-> NADP+ + 1,2-Propanediol
NAD+ + S-(+)-Octan-2-ol <-> NADH + H+ + Octan-2-one
NAD+ + R-(-)-Heptan-2-ol <-> NADH + H+ + Heptan-2-one
NAD+ + R-(+)-cis-Verbenol <-> NADH + H+ + Verbenone
NAD+ + R-(-)-2-Pentanol <-> NADH + H+ + 2-Pentanone
NAD+ + 2-Hexanol <-> NADH + H+ + 2-Hexanone
NAD+ + R-(+)-trans-Bicyclo[2.2.1]heptanol <-> NADH + H+ + Bicyclo[2.2.1]heptanone
NAD+ + R-(-)-2-Hexanol <-> NADH + H+ + 2-Hexanone
NAD+ + S-(-)-2-Methylbutan-1-ol <-> NADH + H+ + S-(-)-2-Methylbutan-1-al
NAD+ + trans-Bicyclo[2.2.1]heptanol <-> NADH + H+ + Bicyclo[2.2.1]heptanone
NAD+ + 1-Phenylethanol <-> NADH + H+ + Acetophenone
NAD+ + cis-4-Methylcyclohexanol <-> NADH + H+ + 4-Methylcyclohexanone
NAD+ + R-(-)-3-Methylbutan-2-ol <-> NADH + H+ + 3-Methylbutan-2-one
NAD+ + S-(+)-2-Hexanol <-> NADH + H+ + 2-Hexanone
NAD+ + Heptan-2-ol <-> NADH + H+ + Heptan-2-one
NAD+ + R-(+)-1-Phenylethanol <-> NADH + H+ + Acetophenone
NAD+ + R-(-)-2-Butanol <-> NADH + H+ + 2-Butanone
NAD+ + 3-Methyl-2-cyclohexanol <-> NADH + H+ + 3-Methyl-2-cyclohexanone
NAD+ + trans-4-Methylcyclohexanol <-> NADH + H+ + 4-Methylcyclohexanone
NAD+ + S-(-)-1-Phenylethanol <-> NADH + H+ + Acetophenone
NAD+ + (S)-(+)-2-Butanol <-> NADH + H+ + 2-Butanone
NAD+ + 4-Methylpentan-1-ol <-> NADH + H+ + 4-Methylpentanal
NAD+ + 4-Heptanol <-> NADH + H+ + 4-Heptanone
NAD+ + S-(+)-3-Methylbutan-2-ol <-> NADH + H+ + 3-Methylbutan-2-one
NAD+ + R-(-)-Octan-2-ol <-> NADH + H+ + Octan-2-one
NAD+ + S-(-)-cis-Bicyclo[2.2.1]heptanol <-> NADH + H+ + Bicyclo[2.2.1]heptanone
NAD+ + S-(+)-Heptan-2-ol <-> NADH + H+ + Heptan-2-one
NAD+ + S-(-)-trans-Bicyclo[2.2.1]heptanol <-> NADH + H+ + Bicyclo[2.2.1]heptanone
H+ + NADPH + 2-Methylpropanal <-> NADP+ + Isobutanol
NADP+ + 2-Pentanol <-> H+ + NADPH + 2-Pentanone
NADP+ + t-Butanol <-> Unknown + H+ + NADPH
NADP+ + 1,2-Butanediol <-> Unknown + H+ + NADPH
NADP+ + 1,3-Butanediol <-> Unknown + H+ + NADPH
NADP+ + (R)-2-Butanol <-> H+ + NADPH + 2-Butanone
NAD+ + 1-Dodecanol <-> NADH + H+ + Dodecanal
NAD+ + (S)-2-Methylbutanol <-> NADH + H+ + (S)-2-Methylbutanal
NADH + S-Nitrosoglutathione <-> NAD+ + Glutathione sulfinamide
NADPH + S-Nitrosoglutathione <-> NADP+ + Glutathione sulfinamide
NADH + H+ + N-Benzyl-3-pyrrolidinone <-> NAD+ + (S)-N-Benzyl-3-pyrrolidinol
NAD+ + (S)-2-Phenylpropanol <-> NADH + H+ + (S)-2-Phenylpropionaldehyde
NAD+ + (R)-2-Phenylpropanol <-> NADH + H+ + (R)-2-Phenylpropionaldehyde
NADH + H+ + 2-Phenylpropionaldehyde <-> NAD+ + 2-Phenylpropanol
NAD+ + 1-Nonanol <-> NADH + H+ + Nonanal
NAD+ + 1-Decanol <-> NADH + H+ + Decanal
NAD+ + 1-Tetradecanol <-> NADH + H+ + Tetradecanal
NAD+ + cis-2-Hexene-1-ol <-> NADH + H+ + cis-2-Hexenal
NAD+ + trans-2-Hexene-1-ol <-> NADH + H+ + trans-2-Hexene-1-al
NAD+ + Prenol <-> NADH + H+ + 3-Methylbut-2-enal
NAD+ + Farnesol <-> NADH + H+ + Farnesal
2 NAD+ + 2-Butene-1,4-diol <-> 2 NADH + 2 H+ + 2-Butendial
2 NAD+ + 1,6-Hexanediol <-> 2 NADH + 2 H+ + 1,6-Hexanedial
2 NAD+ + Octane-1,8-diol <-> 2 NADH + 2 H+ + Octane-1,8-dial
NAD+ + Cinnamyl alcohol <-> NADH + H+ + Cinnamaldehyde
NAD+ + 5beta-cholane-3alpha,7alpha,12alpha,24-tetrol <-> Unknown + NADH + H+
NAD+ + Geraniol <-> NADH + H+ + Geranial
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


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