Enzyme Details

EC Classification

1.1.1.105

Enzyme name
(recommended)

retinol dehydrogenase

Alternative names

retinol:NAD+ oxidoreductase
retinol (vitamin A1) dehydrogenase
MDR
microsomal retinol dehydrogenase
all-trans retinol dehydrogenase
retinal reductase
retinene reductase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + Retinol <-> NADH + H+ + all-trans-Retinal

NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

NAD+ + 11-cis-Retinol <-> NADH + H+ + 11-cis-Retinal

NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + 13-cis-Retinal <-> NADP+ + 13-cis-Retinol

H+ + NADPH + all-trans-Retinal <-> NADP+ + Retinol

H+ + NADPH + 9-cis-Retinal <-> NADP+ + 9-cis-Retinol

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.105