Enzyme Details

 EC Classification 1.1.1.14
 Enzyme name
(recommended)		 L-iditol 2-dehydrogenase
 Alternative names L-iditol:NAD+ 2-oxidoreductase
polyol dehydrogenase
sorbitol dehydrogenase
L-iditol:NAD+ 5-oxidoreductase
L-iditol (sorbitol) dehydrogenase
glucitol dehydrogenase
L-iditol:NAD+ oxidoreductase
NAD+-dependent sorbitol dehydrogenase
NAD+-sorbitol dehydrogenase
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + L-Iditol <-> NADH + H+ + L-Sorbose
NAD+ + D-Mannitol <-> NADH + H+ + D-Fructose
NAD+ + D-Sorbitol <-> NADH + H+ + D-Fructose
NADH + H+ + D-Galactose <-> NAD+ + Galactitol
NAD+ + L-Arabitol <-> NADH + H+ + L-Arabinose
NAD+ + Ribitol <-> NADH + H+ + D-Ribulose
NAD+ + Xylitol <-> NADH + H+ + D-Xylulose
NAD+ + Xylitol <-> NADH + H+ + Xylulose
NAD+ + Sorbitol <-> NADH + H+ + D-Fructose
NADH + H+ + Keto-D-fructose <-> NAD+ + D-Sorbitol
NAD+ + 3-Fluoro-D-sorbitol <-> NADH + H+ + 3-Fluoro-D-fructose
NAD+ + 4-Deoxy-D-sorbitol <-> NADH + H+ + 4-Deoxy-D-fructose
NAD+ + 6-Deoxy-D-sorbitol <-> NADH + H+ + 6-Deoxy-D-fructose
NAD+ + 4-Fluoro-D-sorbitol <-> NADH + H+ + 4-Fluoro-D-fructose
NAD+ + 3-Deoxy-D-sorbitol <-> NADH + H+ + 3-Deoxy-D-glucosone
NAD+ + 6-Fluoro-D-sorbitol <-> NADH + H+ + 6-Fluoro-D-fructose
NAD+ + L-Threitol <-> NADH + H+ + L-Erythrulose
NAD+ + 1-Thiosorbitol <-> NADH + H+ + 1-Thiofructose
NAD+ + Erythritol <-> Unknown + NADH + H+
NADH + H+ + D-Erythrulose <-> NAD+ + D-Threitol
NAD+ + 1-Phenyl-1,2-ethanediol <-> Unknown + NADH + H+
NAD+ + 1-Deoxy-D-glucitol <-> NADH + H+ + 1-Deoxy-D-fructose
NAD+ + 1-Deoxy-D-mannitol <-> NADH + H+ + 1-Deoxy-D-fructose
NAD+ + Glycol <-> NADH + H+ + Glycolaldehyde
NAD+ + L-Arabitol <-> NADH + H+ + L-Ribulose
NAD+ + D-Arabitol <-> NADH + H+ + D-Ribulose
NAD+ + D-Allitol <-> NADH + H+ + D-Psicose
NADH + H+ + D-Sorbose <-> NAD+ + L-Sorbitol
NAD+ + L-Mannitol <-> NADH + H+ + L-Fructose
NAD+ + L-Altritol <-> NADH + H+ + L-Psicose
NAD+ + D-Altritol <-> NADH + H+ + D-Psicose
NAD+ + D-Iditol <-> NADH + H+ + D-Sorbose
NAD+ + Volemitol <-> NADH + H+ + D-allo-2-Heptulose
NAD+ + (meso) D-glycero-L-altro-Heptitol <-> NADH + H+ + D-Sedoheptulose
NAD+ + (meso) D-glycero-D-gulo-Heptitol <-> NADH + H+ + D-gluco-2-Heptulose
NAD+ + (meso) D-glycero-D-allo-Heptitol <-> NADH + H+ + D-allo-2-Heptulose
NAD+ + D-glycero-D-gluco-Heptitol <-> NADH + H+ + D-Sedoheptulose
NAD+ + D-glycero-L-galacto-Heptitol <-> NADH + H+ + D-glycero-L-lyxo-2-Heptulose
NAD+ + D-glycero-L-allo-Heptitol <-> NADH + H+ + D-allo-2-Heptulose
NAD+ + D-glycero-L-gulo-Heptitol <-> NADH + H+ + D-ido-2-Heptulose
NAD+ + (R)-1,2-Butanediol <-> Unknown + NADH + H+
NAD+ + 2,3-Butanediol <-> Unknown + NADH + H+
NAD+ + (S)-2,4-Butanediol <-> Unknown + NADH + H+
NAD+ + (R)-1,2,4-Butanetriol <-> Unknown + NADH + H+
NAD+ + (2S,3S)-1,4-Dimethoxy-2,3-butanediol <-> Unknown + NADH + H+
NAD+ + (2R)-3-Butene-1,2-diol <-> Unknown + NADH + H+
NAD+ + (R)-1,2-Pentanediol <-> Unknown + NADH + H+
NAD+ + (R)-1,2-Hexanediol <-> Unknown + NADH + H+
NAD+ + 1,2,3-Hexanetriol <-> Unknown + NADH + H+
NAD+ + (R)-1,2,6-Hexanetriol <-> Unknown + NADH + H+
NAD+ + 1,2,3-Heptanetriol <-> Unknown + NADH + H+
NAD+ + 1,2,3-Octanetriol <-> Unknown + NADH + H+
NAD+ + erythro-1,2,3-Octanetriol <-> Unknown + NADH + H+
NAD+ + 1,2,7,8-Octanetetrol <-> Unknown + NADH + H+
NAD+ + (R)-1,2,10-Decantriol <-> Unknown + NADH + H+
NAD+ + 6-deoxy-6-nitro-D-Iditol <-> Unknown + NADH + H+
NAD+ + 6-deoxy-L-Mannitol <-> Unknown + NADH + H+
NAD+ + 1-Deoxy-1-amino-sorbitol <-> Unknown + NADH + H+
NAD+ + 3-Deoxysorbitol <-> Unknown + NADH + H+
NAD+ + 6-Deoxysorbitol <-> Unknown + NADH + H+
NAD+ + 1,6-Dideoxysorbitol <-> Unknown + NADH + H+
NAD+ + (S)-1-Phenylethanol <-> NADH + H+ + Acetophenone
NAD+ + (R)-1-Phenyl-2-aminoethanol <-> NADH + H+ + (R)-1-Phenyl-2-aminoethanone
NAD+ + 1-(4-Hydroxyphenyl)-2-aminoethanol <-> NADH + H+ + 2-Amino-1-(4-hydroxyphenyl)ethanone
NAD+ + (S)-1-O-Benzylglycerol <-> Unknown + NADH + H+
NADH + H+ + Phenylglyoxal <-> NAD+ + (R)-2-Hydroxy-2-phenylacetaldehyde
NAD+ + Glycerol <-> NADH + H+ + Dihydroxyacetone
NAD+ + 1-Phenyl-1,2-ethanediol <-> NADH + H+ + 1-Phenyl-2-hydroxyethanone
NAD+ + 1-(4-Hydroxyphenyl)-2-aminoethanol <-> NADH + H+ + 1-(4-Hydroxyphenyl)-2-aminoethanone
NAD+ + 1-Phenyl-2-aminoethanol <-> NADH + H+ + 1-Phenyl-2-aminoethanone
NAD+ + 2-Hydroxy-2-phenylacetaldehyde <-> NADH + H+ + Phenylglyoxal
NAD+ + D-Fructose <-> NADH + H+ + 5-Dehydro-D-fructose
NAD+ + L-Sorbose <-> NADH + H+ + 5-Dehydro-D-fructose
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


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