Enzyme Details

 EC Classification 1.1.1.145
 Enzyme name
(recommended)
3beta-hydroxy-Delta5-steroid dehydrogenase
 Alternative names 3beta-hydroxy-Delta5-steroid:NAD+ 3-oxidoreductase
progesterone reductase
Delta5-3beta-hydroxysteroid dehydrogenase
3beta-hydroxy-5-ene steroid dehydrogenase
3beta-hydroxy steroid dehydrogenase/isomerase
3beta-hydroxy-Delta5-C27-steroid dehydrogenase/isomerase
3beta-hydroxy-Delta5-C27-steroid oxidoreductase
3beta-hydroxy-5-ene-steroid oxidoreductase
steroid-Delta5-3beta-ol dehydrogenase
3beta-HSDH
5-ene-3-beta-hydroxysteroid dehydrogenase
3beta-hydroxy-5-ene-steroid dehydrogenase
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + 3beta-Hydroxyandrost-5-en-17-one <-> NADH + H+ + Androst-4-ene-3,17-dione
NADP+ + 3beta-Hydroxyandrost-5-en-17-one <-> H+ + NADPH + Androst-4-ene-3,17-dione
NAD+ + Pregnenolone <-> NADH + H+ + Progesterone
NADP+ + Pregnenolone <-> H+ + NADPH + Progesterone
NADH + H+ + Testosterone <-> NAD+ + Androst-5-ene-3beta,17beta-diol
NADH + H+ + Cortisol <-> NAD+ + 11beta,17alpha,21-Trihydroxypregnenolone
NAD+ + 3beta-Hydroxy-delta5-steroid <-> NADH + H+ + 3-Oxo-delta5-steroid
NAD+ + 17alpha-Hydroxypregnenolone <-> NADH + H+ + 17alpha-Hydroxyprogesterone
NADP+ + 17alpha-Hydroxypregnenolone <-> H+ + NADPH + 17alpha-Hydroxyprogesterone
NAD+ + 21-Hydroxypregnenolone <-> NADH + H+ + 11-Deoxycorticosterone
NADP+ + 21-Hydroxypregnenolone <-> H+ + NADPH + 11-Deoxycorticosterone
NADH + H+ + 16alpha-Hydroxyandrost-4-ene-3,17-dione <-> NAD+ + 16alpha-Hydroxydehydroepiandrosterone
H+ + NADPH + 16alpha-Hydroxyandrost-4-ene-3,17-dione <-> NADP+ + 16alpha-Hydroxydehydroepiandrosterone
NADH + H+ + 11-Deoxycortisol <-> NAD+ + 17alpha,21-Dihydroxypregnenolone
NAD+ + 3beta-Hydroxyandrost-5-en-17-one <-> NADH + H+ + Androst-5-ene-3,17-dione
NADP+ + 3beta-Hydroxyandrost-5-en-17-one <-> H+ + NADPH + Androst-5-ene-3,17-dione
NADH + H+ + 5beta-Androstane-17beta-ol-3-one <-> NAD+ + Androstanediol
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.1.1.145



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