Enzyme Details

EC Classification

1.1.1.146

Enzyme name
(recommended)

11beta-hydroxysteroid dehydrogenase

Alternative names

11beta-hydroxysteroid:NADP+ 11-oxidoreductase
corticosteroid 11beta-dehydrogenase
beta-hydroxysteroid dehydrogenase
11beta-hydroxy steroid dehydrogenase
corticosteroid 11-reductase
dehydrogenase, 11beta-hydroxy steroid

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + Cortisol <-> NADH + H+ + Cortisone

NADP+ + Cortisol <-> H+ + NADPH + Cortisone

NADP+ + 11beta-Hydroxysteroid <-> H+ + NADPH + 11-Oxosteroid

NAD+ + Corticosterone <-> NADH + H+ + 11-Dehydrocorticosterone

NADP+ + Corticosterone <-> H+ + NADPH + 11-Dehydrocorticosterone

NAD+ + 11beta-Hydroxyandrost-4-ene-3,17-dione <-> NADH + H+ + Adrenosterone

NADP+ + 11beta-Hydroxyandrost-4-ene-3,17-dione <-> H+ + NADPH + Adrenosterone

NAD+ + Tetrahydrocorticosterone <-> NADH + H+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione

NADP+ + Tetrahydrocorticosterone <-> H+ + NADPH + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione

NADP+ + 7alpha-Hydroxycholesterol <-> H+ + NADPH + 7-Ketocholesterol

H+ + NADPH + 7-Ketocholesterol <-> NADP+ + 7-Hydroxycholesterol

NADP+ + 7beta-Hydroxycholesterol <-> H+ + NADPH + 7-Ketocholesterol

NADP+ + Cholesterol <-> H+ + NADPH + 5-Cholesten-3-one

H+ + NADPH + 3-Oxo-5beta-cholanate <-> NADP+ + 3alpha-Hydroxy-5beta-cholanate

NADP+ + Chenodeoxycholate <-> H+ + NADPH + 3alpha-Hydroxy-7-oxo-5beta-cholanate

NADP+ + 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate <-> Unknown + H+ + NADPH

NADP+ + 11-Dehydrocorticosterone <-> Unknown + H+ + NADPH

NADP+ + 3beta-Hydroxyandrost-5-en-17-one <-> H+ + NADPH + Androst-5-ene-3,17-dione

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.146