Enzyme Details

EC Classification

1.1.1.149

Enzyme name
(recommended)

20alpha-hydroxysteroid dehydrogenase

Alternative names

20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
20alpha-hydroxy steroid dehydrogenase
20alpha-hydroxy steroid dehydrogenase
20alpha-HSD
20alpha-HSDH

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NADP+ + Glycerol <-> H+ + NADPH + D-Glyceraldehyde

NAD+ + 20alpha-Hydroxy-4-pregnen-3-one <-> NADH + H+ + Progesterone

NADP+ + 20alpha-Hydroxy-4-pregnen-3-one <-> H+ + NADPH + Progesterone

NAD+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> NADH + H+ + 17alpha-Hydroxyprogesterone

NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> H+ + NADPH + 17alpha-Hydroxyprogesterone

H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol

H+ + NADPH + Phenylglyoxal <-> Unknown + NADP+

H+ + NADPH + Ethyl 3-oxobutanoate <-> NADP+ + Ethyl 3-hydroxybutanoate

H+ + NADPH + Cyclohexan-1,2-dione <-> NADP+ + 2-Hydroxycyclohexanone

NADP+ + 5alpha-Pregnan-3alpha,20alpha-diol <-> H+ + NADPH + 3alpha-Hydroxy-5alpha-pregnan-20-one

H+ + NADPH + Corticosterone <-> NADP+ + 11beta,20alpha,21-Trihydroxy-4-pregnene-3-one

H+ + NADPH + Camphorquinone <-> Unknown + NADP+

H+ + NADPH + Cortisone <-> NADP+ + 11beta,17alpha,20alpha,21-Tetrahydroxy-4-pregnene-3-one

H+ + NADPH + 2,4-Pentanedione <-> NADP+ + 4-Hydroxypentan-2-one

NADP+ + Benzene dihydrodiol <-> H+ + NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one

H+ + NADPH + 5beta-Pregnane-3,20-dione <-> NADP+ + 20alpha-Hydroxy-5beta-pregnan-3-one

H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NADP+ + 17alpha,20alpha,21-Trihydroxy-5beta-pregnane-3,11-dione

H+ + NADPH + 17alpha-Hydroxypregnenolone <-> NADP+ + 3beta,17alpha-Dihydroxypregn-5-en-20-ol

NADP+ + Pregnanediol <-> H+ + NADPH + 3alpha-Hydroxy-5beta-pregnane-20-one

H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,20-dione <-> NADP+ + 17alpha,20alpha,21-Trihydroxy-5beta-pregnane-3-one

H+ + NADPH + Pregnenolone <-> NADP+ + 3beta-Hydroxypregn-5-en-20-ol

H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole

H+ + NADPH + 3beta-Hydroxy-5beta-pregnane-20-one <-> NADP+ + 5beta-Pregnan-3beta,20alpha-diol

H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol

NADP+ + 1,2,3,4-Tetrahydronaphth-1-ol <-> H+ + NADPH + alpha-Tetralone

NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione

H+ + NADPH + 5alpha-Pregnan-3alpha,21-diol-20-one <-> NADP+ + 5alpha-Pregnan-3alpha,20alpha,21-triol

H+ + NADPH + 5alpha-Pregnane-3,20-dione <-> NADP+ + 20alpha-Hydroxy-5alpha-pregnan-3-one

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.149

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