Enzyme Details

EC Classification

1.1.1.151

Enzyme name
(recommended)

21-hydroxysteroid dehydrogenase (NADP+)

Alternative names

21-hydroxysteroid:NADP+ 21-oxidoreductase
21-hydroxy steroid dehydrogenase
21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase
21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate)
NADP+-21-hydroxysteroid dehydrogenase
21-hydroxysteroid dehydrogenase (NADP+)

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

H+ + NADPH + Pregnan-21-al <-> NADP+ + Pregnan-21-ol

H+ + NADPH + 21-Dehydrocortisone <-> NADP+ + Cortisone

H+ + NADPH + 21-Dehydrocortisol <-> NADP+ + Cortisol

H+ + NADPH + 21-Dehydro-11-deoxycortisol <-> NADP+ + 11-Deoxycortisol

H+ + NADPH + 21-Dehydro-delta1-cortisol <-> NADP+ + delta1-Cortisol

H+ + NADPH + 21-Dehydro-11-deoxycorticosterone <-> NADP+ + 11-Deoxycorticosterone

H+ + NADPH + 21-Dehydrocorticosterone <-> NADP+ + Corticosterone

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.151