Enzyme Details

EC Classification

1.1.1.184

Enzyme name
(recommended)

carbonyl reductase (NADPH)

Alternative names

secondary-alcohol:NADP+ oxidoreductase
aldehyde reductase 1
prostaglandin 9-ketoreductase
xenobiotic ketone reductase
NADPH-dependent carbonyl reductase
ALR3
carbonyl reductase
nonspecific NADPH-dependent carbonyl reductase
carbonyl reductase (NADPH2)

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

Ethanol + NADP+ <-> H+ + NADPH + Acetaldehyde

NAD+ + Ethanol <-> NADH + H+ + Acetaldehyde

H+ + NADPH + Acetone <-> NADP+ + 2-Propanol

NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione

NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

H+ + NADPH + Testosterone <-> NADP+ + 4-Androstenediol

NADP+ + Prostaglandin F2alpha <-> H+ + NADPH + Prostaglandin E2

NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> H+ + NADPH + 17alpha-Hydroxyprogesterone

NADP+ + R-CHOH-R' <-> H+ + NADPH + R-CO-R'

NAD+ + Indan-1-ol <-> NADH + H+ + Indanone

NADP+ + Indan-1-ol <-> H+ + NADPH + Indanone

NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione

NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione

H+ + NADPH + 4-Oxonon-2-enal <-> NADP+ + 1-Hydroxynon-2-en-4-one

H+ + NADPH + 4-Oxonon-2-enal <-> NADP+ + 4-Hydroxy-2-nonenal

H+ + NADPH + 4-Oxonon-2-enal <-> NADP+ + 4-Oxononanal

H+ + NADPH + Glutathione-4-oxonon-2-enal <-> NADP+ + Glutathione-1-hydroxynon-2-en-4-one

H+ + NADPH + Glutathione-4-oxonon-2-enal <-> NADP+ + Glutathione-4-hydroxynon-2-enal

H+ + NADPH + Glutathione-4-oxonon-2-enal <-> NADP+ + Glutathione-4-oxononanal

H+ + NADPH + Glyceraldehyde <-> NADP+ + Glycerol

H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol

H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol

H+ + NADPH + Propanal <-> NADP+ + 1-Propanol

H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol

ATP + L-Glutamate + L-Allylglycine <-> ADP + Phosphate + L-gamma-Glutamyl-L-allylglycine

NAD+ + Chloral hydrate <-> NADH + H+ + Trichloroacetate

H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol

H+ + NADPH + Phenylglyoxal <-> Unknown + NADP+

NADP+ + (R)-Indan-1-ol <-> H+ + NADPH + Indanone

NADP+ + (S)-Indan-1-ol <-> H+ + NADPH + Indanone

NAD+ + (S)-2-Butanol <-> NADH + H+ + 2-Butanone

NADH + H+ + 2-Butanone <-> NAD+ + 2-Butanol

NADP+ + (S)-2-Butanol <-> H+ + NADPH + 2-Butanone

H+ + NADPH + 2-Butanone <-> NADP+ + 2-Butanol

H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol

NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol

NADH + H+ + 5beta-Androstane-17beta-ol-3-one <-> NAD+ + 5beta-Androstane-3alpha,17beta-diol

NADH + H+ + Acetone <-> NAD+ + 2-Propanol

NADH + H+ + Cyclohex-2-enone <-> NAD+ + Cyclohex-2-en-1-ol

NADP+ + Cyclohex-2-en-1-ol <-> H+ + NADPH + Cyclohex-2-enone

H+ + NADPH + Cyclohex-2-enone <-> NADP+ + Cyclohex-2-en-3-ol

H+ + NADPH + Cyclohexanone <-> NADP+ + Cyclohexanol

NAD+ + (R)-Indan-1-ol <-> NADH + H+ + Indanone

NAD+ + (S)-Indan-1-ol <-> NADH + H+ + Indanone

H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin

NADH + H+ + Pyridine-3-aldehyde <-> NAD+ + 3-Pyridinemethanol

NADH + H+ + Pyridine-4-aldehyde <-> NAD+ + 4-Pyridinemethanol

NADP+ + Chloral hydrate <-> H+ + NADPH + Trichloroacetate

H+ + NADPH + Ethyl 3-methyl-2-oxobutanoate <-> NADP+ + Ethyl 3-methyl-2-hydroxybutanoate

H+ + NADPH + Ketopantoyl lactone <-> Unknown + NADP+

H+ + NADPH + Ethyl 4-chloro-3-oxobutanoate <-> NADP+ + (S)-Ethyl 4-chloro-3-hydroxybutanoate

H+ + NADPH + Ethyl 2-oxobutanoate <-> NADP+ + Ethyl 2-hydroxybutanoate

H+ + NADPH + 2,3-Pentanedione <-> Unknown + NADP+

H+ + NADPH + Methyl 4-chloro-3-oxobutanoate <-> NADP+ + Methyl 4-chloro-3-hydroxybutanoate

H+ + NADPH + Ethyl 2-chloro-3-oxobutanoate <-> NADP+ + Ethyl 2-chloro-3-hydroxybutanoate

H+ + NADPH + Methyl 2-chloro-3-oxobutanoate <-> NADP+ + Methyl 2-chloro-3-hydroxybutanoate

H+ + NADPH + Ethyl pyruvate <-> Unknown + NADP+

H+ + NADPH + 2-Nitrobenzaldehyde <-> NADP+ + 2-Nitrobenzyl alcohol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstan-3beta,17beta-diol

H+ + NADPH + Daunorubicin <-> Unknown + NADP+

H+ + NADPH + 4-Benzoylpyridine <-> Unknown + NADP+

NAD+ + Cyclohexanol <-> NADH + H+ + Cyclohexanone

H+ + NADPH + Menadione <-> NADP+ + Menadiol

NADH + Methyl-1,4-benzoquinone <-> NAD+ + Methylhydroquinone

NADPH + Methyl-1,4-benzoquinone <-> NADP+ + Methylhydroquinone

NADPH + Crotonaldehyde <-> NADP+ + 2-Buten-1-ol

NADH + Crotonaldehyde <-> NAD+ + 2-Buten-1-ol

NADH + Benzalacetone <-> Unknown + NAD+

NADPH + Benzalacetone <-> Unknown + NADP+

NADH + 4-Benzoylpyridine <-> Unknown + NAD+

NADH + H+ + Menadione <-> NAD+ + Menadiol

NADH + H+ + 4-Nitroacetophenone <-> NAD+ + 1-(4-Nitrophenyl)ethanol

H+ + NADPH + Nonanal <-> NADP+ + 1-Nonanol

H+ + NADPH + 1-Octanal <-> NADP+ + 1-Octanol

H+ + NADPH + Pyridine-4-aldehyde <-> NADP+ + 4-Pyridinemethanol

H+ + NADPH + Ubiquinone-1 <-> NADP+ + Ubiquinol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + Androstanediol

NADP+ + Prostaglandin B1 <-> Unknown + H+ + NADPH

H+ + NADPH + 3-Benzoylpyridine <-> Unknown + NADP+

H+ + NADPH + Adamantanone <-> NADP+ + Adamantanol

H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3beta,17beta-diol

H+ + NADPH + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol

H+ + NADPH + 5alpha-Androstane-3,17-dione <-> NADP+ + 5alpha-Androstane-3beta-ol-17-one

H+ + NADPH + 5beta-Androstane-3,17-dione <-> NADP+ + 5beta-Androstane-3beta-ol-17-one

NADP+ + 5beta-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione

H+ + NADPH + S-Nitrosoglutathione <-> NADP+ + GSN

H+ + NADPH + 4-Benzoylpyridine <-> NADP+ + Phenyl(pyridin-4-yl)methanol

H+ + NADPH + Adriamycin <-> NADP+ + Doxorubicinol

H+ + NADPH + Daunorubicin <-> NADP+ + 13-Dihydrodaunorubicin

H+ + NADPH + (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate <-> Unknown + NADP+

H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole

H+ + NADPH + 2,3-Hexanedione <-> NADP+ + 3-Hydroxyhexan-2-one

H+ + NADPH + 3,4-Hexanedione <-> NADP+ + Propioin

H+ + NADPH + 2,3-Heptanedione <-> NADP+ + 3-Hydroxyheptan-2-one

H+ + NADPH + 4-Carboxybenzaldehyde <-> NADP+ + 4-Carboxybenzyl alcohol

NADP+ + Prostaglandin B2 <-> H+ + NADPH + (5Z,13E)-9,15-Dioxoprosta-5,8(12),13-trien-1-oic acid

H+ + NADPH + 5alpha-Androstane-3,17-dione <-> NADP+ + 5alpha-Androstan-3alpha-ol-17-one

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

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