Enzyme Details

EC Classification

1.1.1.2

Enzyme name
(recommended)

alcohol dehydrogenase (NADP+)

Alternative names

alcohol:NADP+ oxidoreductase
aldehyde reductase (NADPH2)
NADP-alcohol dehydrogenase
NADP+-aldehyde reductase
NADP+-dependent aldehyde reductase
NADPH-aldehyde reductase
NADPH-dependent aldehyde reductase
nonspecific succinic semialdehyde reductase
ALR 1
low-Km aldehyde reductase
high-Km aldehyde reductase
alcohol dehydrogenase (NADP)

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

Ethanol + NADP+ <-> H+ + NADPH + Acetaldehyde

NADP+ + Primary alcohol <-> H+ + NADPH + Aldehyde

NADP+ + Glycerol <-> H+ + NADPH + D-Glyceraldehyde

NADP+ + 6-Hydroxyhexanoate <-> H+ + NADPH + 6-Oxohexanoate

NADP+ + trans-1,2-Dihydrobenzene-1,2-diol <-> H+ + NADPH + Catechol

NAD+ + Glycerol <-> NADH + H+ + D-Glyceraldehyde

NADP+ + Glycerol <-> H+ + NADPH + Dihydroxyacetone

H+ + NADPH + D-Galactose <-> NADP+ + Galactitol

NADP+ + Xylitol <-> H+ + NADPH + D-Xylose

NADP+ + L-Gulonate <-> H+ + NADPH + D-Glucuronate

NAD+ + 4-Hydroxybutanoate <-> NADH + H+ + Succinate semialdehyde

NADP+ + L-Arabitol <-> H+ + NADPH + L-Arabinose

NADP+ + D-Sorbitol <-> H+ + NADPH + alpha-D-Glucose

NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione

NADP+ + (R)-Mevalonate <-> H+ + NADPH + Mevaldate

NAD+ + 1-Propanol <-> NADH + H+ + Propanal

NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

H+ + NADPH + Methylglyoxal <-> NADP+ + Hydroxyacetone

NADP+ + Indole-3-ethanol <-> H+ + NADPH + Indole-3-acetaldehyde

H+ + NADPH + Cinnamaldehyde <-> NADP+ + Cinnamyl alcohol

NADP+ + L-Gulono-1,4-lactone <-> H+ + NADPH + D-Glucurono-3,6-lactone

NADH + H+ + Butanal <-> NAD+ + 1-Butanol

H+ + NADPH + Butanal <-> NADP+ + 1-Butanol

NADP+ + sn-Glycerol 1-phosphate <-> Glycerone phosphate + H+ + NADPH

NAD+ + 3-Methylbutanol <-> NADH + H+ + 3-Methylbutanal

NADP+ + 3-Methylbutanol <-> H+ + NADPH + 3-Methylbutanal

NADP+ + Alcohol <-> H+ + NADPH + (+)-Camphorquinone

H+ + NADPH + 4-Cyanobenzaldehyde <-> NADP+ + 4-Cyanobenzyl alcohol

H+ + NADPH + 4-Carboxybenzaldehyde <-> NADP+ + 4-Carboxybenzyl alcohol

H+ + NADPH + 3-Pyridinecarboxaldehyde <-> NADP+ + 3-Pyridinemethanol

NADP+ + Acenaphthen-1-ol <-> H+ + NADPH + 1-Acenaphthenone

H+ + NADPH + Benzaldehyde <-> NADP+ + Benzyl alcohol

H+ + NADPH + Glyceraldehyde <-> NADP+ + Glycerol

H+ + NADPH + D-Ribose <-> NADP+ + Ribitol

H+ + NADPH + Glycolaldehyde <-> NADP+ + Glycol

H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol

H+ + NADPH + Octadecanal <-> NADP+ + Stearyl alcohol

H+ + NADPH + o-Nitrobenzaldehyde <-> NADP+ + o-Nitrobenzyl alcohol

H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol

NADH + H+ + Glyceraldehyde <-> NAD+ + Glycerol

H+ + NADPH + Propanal <-> NADP+ + 1-Propanol

H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol

H+ + NADPH + Glucose <-> NADP+ + Sorbitol

H+ + NADPH + 3-Chlorobenzaldehyde <-> NADP+ + 3-Chlorobenzyl alcohol

H+ + NADPH + 3-Methoxybenzaldehyde <-> NADP+ + 3-Methoxybenzyl alcohol

H+ + NADPH + 4-Hydroxyphenylacetaldehyde <-> NADP+ + 4-Hydroxyphenylethanol

H+ + NADPH + 4-Hydroxyphenylglycolaldehyde <-> NADP+ + 4-Hydroxyphenylethyl alcohol

H+ + NADPH + 4-Methoxybenzaldehyde <-> NADP+ + 4-Methoxybenzyl alcohol

H+ + NADPH + 4-Tolualdehyde <-> NADP+ + Toluene

NAD+ + 1-Pentanol <-> NADH + H+ + 1-Pentanal

NAD+ + 1-Hexanol <-> NADH + H+ + Hexanal

H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol

H+ + NADPH + 2-Deoxy-D-glucose <-> NADP+ + 2-Deoxy-D-sorbitol

H+ + NADPH + 1-Pentanal <-> NADP+ + 1-Pentanol

H+ + NADPH + Hexanal <-> NADP+ + 1-Hexanol

H+ + NADPH + 2-Butanone <-> NADP+ + 2-Butanol

H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + Cyclohexanone <-> NADP+ + Cyclohexanol

H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin

NADH + H+ + Pyridine-4-aldehyde <-> NAD+ + 4-Pyridinemethanol

H+ + NADPH + 2-Nitrobenzaldehyde <-> NADP+ + 2-Nitrobenzyl alcohol

NADP+ + Lactaldehyde <-> H+ + NADPH + Methylglyoxal

H+ + NADPH + 13-cis-Retinal <-> NADP+ + 13-cis-Retinol

NADPH + Benzalacetone <-> Unknown + NADP+

H+ + NADPH + all-trans-Retinal <-> NADP+ + Retinol

H+ + NADPH + D-Galacturonate <-> NADP+ + L-Galactonate

H+ + NADPH + Phenylglyoxal <-> NADP+ + 2-Hydroxyacetophenone

H+ + NADPH + Ethyl 3-oxobutanoate <-> NADP+ + Ethyl 3-hydroxybutanoate

H+ + NADPH + L-Glyceraldehyde <-> NADP+ + Glycerol

H+ + NADPH + Cyclohexan-1,2-dione <-> NADP+ + 2-Hydroxycyclohexanone

H+ + NADPH + Dodecanal <-> NADP+ + 1-Dodecanol

NADP+ + trans-2-Hexenol <-> H+ + NADPH + trans-2-Hexenal

H+ + NADPH + Heptanal <-> NADP+ + Heptanol

NADH + H+ + 2-Methylbutanal <-> NAD+ + 2-Methylbutanol

NADH + H+ + Heptanal <-> NAD+ + Heptanol

H+ + NADPH + 2-Methylbutanal <-> NADP+ + 2-Methylbutanol

H+ + NADPH + D-Lactaldehyde <-> NADP+ + 1,2-Propanediol

H+ + NADPH + Hydroxyacetone <-> NADP+ + 1,2-Propanediol

H+ + NADPH + Glyceraldehyde 3-phosphate <-> NADP+ + sn-Glycerol 3-phosphate

NADP+ + (S)-4-Phenyl-2-butanol <-> H+ + NADPH + Benzylacetone

H+ + NADPH + Phenylacetone <-> NADP+ + (S)-1-Phenyl-2-propanol

H+ + NADPH + Succinate semialdehyde <-> NADP+ + 4-Hydroxybutanoate

H+ + NADPH + 2-Chlorobenzaldehyde <-> NADP+ + 2-Chlorobenzyl alcohol

H+ + NADPH + 4-Chlorobenzaldehyde <-> NADP+ + p-Chlorobenzyl alcohol

H+ + NADPH + 1-Octanal <-> NADP+ + 1-Octanol

H+ + NADPH + Pyridine-2-aldehyde <-> NADP+ + 2-Pyridinylmethanol

H+ + NADPH + 2-Carboxybenzaldehyde <-> NADP+ + 2-(Hydroxymethyl)benzoic acid

H+ + NADPH + Pyridine-4-aldehyde <-> NADP+ + 4-Pyridinemethanol

H+ + NADPH + 1,2-Naphthoquinone <-> NADP+ + Naphthalene-1,2-diol

H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole

H+ + NADPH + 16-Ketoestrone <-> NADP+ + 16-Hydroxyestrone

H+ + NADPH + 16-Hexadecanal <-> NADP+ + 1-Hexadecanol

H+ + NADPH + N,N-Dimethyl-4-nitrosoaniline <-> NADP+ + N,N-Dimethyl-1,4-phenylenediamine

H+ + NADPH + N,N-Diethyl-4-nitrosoaniline <-> NADP+ + N,N-Diethyl-p-phenylenediamine

NADP+ + p-Nitrosophenol <-> H+ + NADPH + p-Nitrosocyclohexa-2,5-dien-1-one

H+ + NADPH + 4-Nitroso-N-phenylaniline <-> NADP+ + 4-Aminodiphenylamine

H+ + NADPH + p-Nitroso-N-dimethylaniline <-> NADP+ + N,N-Dimethyl-1,4-phenylenediamine

NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

H+ + NADPH + Aflatoxin B1 dihydrodiol <-> NADP+ + Aflatoxin B1 dialcohol

H+ + NADPH + 3-Oxopropanoate <-> NADP+ + 3-Hydroxypropanoate

NADP+ + (R)-2-Butanol <-> H+ + NADPH + 2-Butanone

NADH + H+ + Methyl acetoacetate <-> NAD+ + Methyl 3-hydroxybutanoate

NADH + H+ + Acetone <-> NAD+ + 2-Propanol

H+ + NADPH + Methyl acetoacetate <-> NADP+ + Methyl 3-hydroxybutanoate

H+ + NADPH + Acetone <-> NADP+ + 2-Propanol

2 H+ + 2 NADPH + Camphorquinone <-> 2 NADP+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol

H+ + NADPH + 4-Hydroxybenzaldehyde <-> NADP+ + p-Hydroxybenzyl alcohol

NADP+ + Coniferyl alcohol <-> H+ + NADPH + Coniferaldehyde

NADPH + Crotonaldehyde <-> NADP+ + 2-Buten-1-ol

H+ + NADPH + Adriamycin <-> NADP+ + Doxorubicinol

NADP+ + 5beta-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione

NAD+ + Isobutanol <-> NADH + H+ + 2-Methylpropanal

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.2

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