Enzyme Details

EC Classification

1.1.1.209

Enzyme name
(recommended)

3(or 17)alpha-hydroxysteroid dehydrogenase

Alternative names

3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase
3(17)alpha-hydroxysteroid dehydrogenase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

H+ + NADPH + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NADP+ + Pregnanediol

H+ + NADPH + 3-Oxo-5beta-cholanate <-> NADP+ + 3alpha-Hydroxy-5beta-cholanate

H+ + NADPH + Androst-4-ene-3,17-dione <-> NADP+ + Epitestosterone

NADP+ + 5beta-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5beta-Pregnan-21-ol-3,20-dione

NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione

NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione

NADP+ + 5alpha-Pregnan-3alpha,20alpha-diol <-> H+ + NADPH + 20alpha-Hydroxy-5alpha-pregnan-3-one

NADP+ + 5alpha-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5alpha-Pregnane-21-ol-3,20-dione

NADP+ + 17alpha-Hydroxy-5alpha-androstan-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

NADP+ + 17alpha-Hydroxy-5beta-androstan-3-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione

NADP+ + 17alpha-Hydroxyestr-4-en-3-one <-> H+ + NADPH + Estr-4-en-3,17-dione

NADP+ + Estradiol-17alpha <-> H+ + NADPH + Estrone

NADP+ + Benzene dihydrodiol <-> H+ + NADPH + Catechol

NADP+ + (R)-Indan-1-ol <-> H+ + NADPH + Indanone

NADP+ + Androst-5-ene-3beta,17alpha-diol <-> H+ + NADPH + Androst-5-ene-3beta-ol-17-one

NADP+ + 3alpha-Hydroxy-5alpha-pregnan-20-one <-> H+ + NADPH + 5alpha-Pregnane-3,20-dione

NADP+ + 5beta-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5beta-Pregnane-21-ol-3,20-dione

H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol

NADP+ + Tetrahydrocorticosterone <-> H+ + NADPH + 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione

H+ + NADPH + Testosterone <-> NADP+ + Androst-4-ene-3alpha,17beta-diol

H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NADP+ + Tetrahydrocortisone

H+ + NADPH + 11-Deoxycorticosterone <-> NADP+ + 3alpha,21-Dihydroxypregn-4-ene-20-one

H+ + NADPH + 16-Ketoestrone <-> NADP+ + 3,17alpha-Dihydroxy-1,3,5(10)-estratriene-16-one

H+ + NADPH + 3beta-Hydroxyandrost-5-en-17-one <-> NADP+ + Androst-5-ene-3beta,17alpha-diol

H+ + NADPH + 3beta-Hydroxyandrost-5-en-17-one 3-sulfate <-> NADP+ + 3beta,17alpha-Dihydroxyandrost-5-ene sulfate

H+ + NADPH + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADP+ + 5beta-Androstane-3alpha,17alpha-diol

H+ + NADPH + 4-Androsten-3alpha-ol-17-one <-> NADP+ + 4-Androsten-3alpha,17alpha-diol

2 H+ + 2 NADPH + (1R)-(-)-Camphorquinone <-> 2 NADP+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol

2 H+ + 2 NADPH + (1S)-(+)-Camphorquinone <-> 2 NADP+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol

2 H+ + 2 NADPH + Acenaphthenequinone <-> 2 NADP+ + Acenaphthene-1,2-diol

2 H+ + 2 NADPH + 1-Phenylisatin <-> 2 NADP+ + 1-Phenylindole-2,3-diol

H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol

H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol

NAD+ + Epitestosterone <-> NADH + H+ + Androst-4-ene-3,17-dione

NAD+ + 3alpha-Hydroxy-5alpha-pregnan-20-one <-> NADH + H+ + 5alpha-Pregnane-3,20-dione

H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.209