Enzyme Details

EC Classification

1.1.1.213

Enzyme name
(recommended)

3alpha-hydroxysteroid dehydrogenase (A-specific)

Alternative names

3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione

H+ + NADPH + Progesterone <-> NADP+ + 5beta-Pregnane-3,20-dione

NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

NADP+ + Indan-1-ol <-> H+ + NADPH + Indanone

NAD+ + 3alpha-Hydroxy-5beta-cholanate <-> NADH + H+ + 3-Oxo-5beta-cholanate

NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione

NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione

NAD+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha-Hydroxy-5beta-cholestan-3-one

NADP+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha-Hydroxy-5beta-cholestan-3-one

NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

NAD+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione

NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione

NADP+ + 3beta-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione

NADP+ + Acenaphthen-1-ol <-> H+ + NADPH + 1-Acenaphthenone

NADP+ + Benzene dihydrodiol <-> H+ + NADPH + Catechol

H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol

H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol

H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol

H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol

NAD+ + 3alpha-Hydroxy-5alpha-pregnan-20-one <-> NADH + H+ + 5alpha-Pregnane-3,20-dione

NADP+ + (R)-Indan-1-ol <-> H+ + NADPH + Indanone

NADP+ + (S)-Indan-1-ol <-> H+ + NADPH + Indanone

H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol

NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol

H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin

H+ + NADPH + 2-Nitrobenzaldehyde <-> NADP+ + 2-Nitrobenzyl alcohol

H+ + NADPH + 4-Benzoylpyridine <-> Unknown + NADP+

H+ + NADPH + Menadione <-> NADP+ + Menadiol

NADH + H+ + p-Nitrobenzaldehyde <-> NAD+ + p-Nitrobenzyl alcohol

H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + Androstanediol

NADH + H+ + 9,10-Phenanthroquinone <-> NAD+ + Phenanthrene-9,10-diol

H+ + NADPH + 3-Oxo-5beta-cholanate <-> NADP+ + 3alpha-Hydroxy-5beta-cholanate

H+ + NADPH + Camphorquinone <-> Unknown + NADP+

NADP+ + Benzene dihydrodiol <-> H+ + NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one

H+ + NADPH + 4-Chlorobenzaldehyde <-> NADP+ + p-Chlorobenzyl alcohol

NADP+ + 1,2,3,4-Tetrahydronaphth-1-ol <-> H+ + NADPH + alpha-Tetralone

H+ + NADPH + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NADP+ + Pregnanediol

NAD+ + Glycolithocholate <-> NADH + H+ + 3-Oxo-5beta-glycocholanate

NAD+ + 5beta-Pregnane-3alpha,21-diol-20-one <-> NADH + H+ + 5beta-Pregnane-21-ol-3,20-dione

NAD+ + Glycochenodeoxycholic acid <-> NADH + H+ + 7alpha-Hydroxy-3-oxo-5-beta-cholanoyl glycinate

NADP+ + Glycolithocholate <-> H+ + NADPH + 3-Oxo-5beta-glycocholanate

NADP+ + 5beta-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5beta-Pregnan-21-ol-3,20-dione

NADP+ + Glycochenodeoxycholate <-> H+ + NADPH + 7alpha-Hydroxy-3-oxo-5-beta-cholanoyl glycinate

H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NADP+ + Tetrahydrocortisone

NADH + H+ + 5alpha-Pregnane-21-ol-3,20-dione <-> NAD+ + 5alpha-Pregnan-3alpha,21-diol-20-one

NADH + H+ + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NAD+ + Tetrahydrocortisone

H+ + NADPH + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NADP+ + 6-tert-Butyl-2,3-epoxy-4(S)-hydroxy-5-cyclohexene-1-one

NADH + H+ + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NAD+ + 6-tert-Butyl-2,3-epoxy-4(S)-hydroxy-5-cyclohexene-1-one

H+ + NADPH + t-Butyl-p-benzoquinone <-> NADP+ + t-Butyl-p-hydrobenzoquinone

NADH + H+ + Dihydrocortisone <-> NAD+ + Tetrahydrocortisone

NADP+ + Tetrahydrocortisone <-> H+ + NADPH + Dihydrocortisone

NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

2 NADP+ + trans-Cyclohexa-3,5-diene-1,2-diol <-> 2 H+ + 2 NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one

NADP+ + 3alpha-Hydroxyhexobarbital <-> H+ + NADPH + 3-Oxohexobarbital

NADP+ + 3beta-Hydroxyhexobarbital <-> H+ + NADPH + 3-Oxohexobarbital

NADP+ + 5alpha-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5alpha-Pregnane-21-ol-3,20-dione

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.213