Enzyme Details

EC Classification

1.1.1.272

Enzyme name
(recommended)

(R)-2-hydroxyacid dehydrogenase

Alternative names

(R)-2-hydroxyacid:NAD(P)+ oxidoreductase
(R)-sulfolactate:NAD(P)+ oxidoreductase
L-sulfolactate dehydrogenase
ComC
(R)-sulfolactate dehydrogenase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + 2-Hydroxybutyrate <-> NADH + H+ + 2-Oxobutyrate

NAD+ + (R)-Mandelate <-> NADH + H+ + alpha-Oxo-benzeneacetic acid

NAD+ + (S)-3-Sulfolactate <-> NADH + H+ + 3-Sulfopyruvate

NADP+ + (S)-3-Sulfolactate <-> H+ + NADPH + 3-Sulfopyruvate

NADH + H+ + 2-Oxoglutarate <-> NAD+ + 2-Hydroxyglutarate

NADH + H+ + 1-Oxo-1,3,4,6-hexanetetracarboxylic acid <-> NAD+ + 1-Hydroxy-1,3,4,6-hexanetetracarboxylic acid

NAD+ + (S)-2-Hydroxyglutarate <-> NADH + H+ + 2-Oxoglutarate

NADH + H+ + 4-Methyl-2-oxopentanoate <-> NAD+ + 2-Hydroxyisocaproate

NADH + H+ + 2-Oxopentanoate <-> NAD+ + 2-Hydroxyvalerate

NADH + H+ + Phenylpyruvate <-> NAD+ + 2-Hydroxy-3-phenylpropanoic acid

NADH + H+ + alpha-Ketovaline <-> NAD+ + Hydroxyisovalerate

NADH + H+ + 2-Oxohexanoate <-> NAD+ + 2-Hydroxycaproate

H+ + NADPH + 3-Methyl-2-oxopentanoate <-> NADP+ + D-2-Hydroxy-3-methylpentanoate

H+ + NADPH + 4-Methyl-2-oxopentanoate <-> NADP+ + D-2-Hydroxyisocaproate

H+ + NADPH + 2-Oxobutyrate <-> NADP+ + D-2-Hydroxybutyrate

Pyruvate + H+ + NADPH <-> NADP+ + D-Lactate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.272

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