Enzyme Details

EC Classification

1.1.1.284

Enzyme name
(recommended)

S-(hydroxymethyl)glutathione dehydrogenase

Alternative names

S-(hydroxymethyl)glutathione:NAD+ oxidoreductase
NAD-linked formaldehyde dehydrogenase (incorrect)
formaldehyde dehydrogenase (incorrect)
formic dehydrogenase (incorrect)
class III alcohol dehydrogenase
ADH3
chi-ADH
FDH (incorrect)
formaldehyde dehydrogenase (glutathione) (incorrect)
GS-FDH (incorrect)
glutathione-dependent formaldehyde dehydrogenase (incorrect)
NAD-dependent formaldehyde dehydrogenase
GD-FALDH
NAD- and glutathione-dependent formaldehyde dehydrogenase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + Reduced glutathione + Formaldehyde <-> NADH + H+ + S-Formylglutathione

NAD+ + Reduced glutathione + D-Lactaldehyde <-> NADH + H+ + (R)-S-Lactoylglutathione

NAD+ + Ethanol <-> NADH + H+ + Acetaldehyde

NAD+ + 1-Octanol <-> NADH + H+ + 1-Octanal

NAD+ + 12-Hydroxydodecanoic acid <-> NADH + H+ + 12-Oxododecanoic acid

NAD+ + 1-Pentanol <-> NADH + H+ + 1-Pentanal

Reduced glutathione + Formaldehyde <-> S-(Hydroxymethyl)glutathione

NAD+ + S-(Hydroxymethyl)glutathione <-> NADH + H+ + S-Formylglutathione

NAD+ + S-(Hydroxymethyl)-8-thiooctanoate <-> NADH + H+ + S-Formyl-8-thiooctanoate

NAD+ + H2O + Formaldehyde + S-Ethyl glutathione <-> NADH + H+ + Ethanol + S-Formylglutathione

NAD+ + Reduced glutathione + Methylglyoxal <-> NADH + H+ + S-Pyruvylglutathione

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.284