Enzyme Details

 EC Classification 1.1.1.35
 Enzyme name
(recommended)
3-hydroxyacyl-CoA dehydrogenase
 Alternative names (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
beta-hydroxyacyl dehydrogenase
beta-keto-reductase
3-keto reductase
3-hydroxyacyl coenzyme A dehydrogenase
beta-hydroxyacyl-coenzyme A synthetase
beta-hydroxyacylcoenzyme A dehydrogenase
beta-hydroxybutyrylcoenzyme A dehydrogenase
3-hydroxyacetyl-coenzyme A dehydrogenase
L-3-hydroxyacyl coenzyme A dehydrogenase
L-3-hydroxyacyl CoA dehydrogenase
beta-hydroxyacyl CoA dehydrogenase
3beta-hydroxyacyl coenzyme A dehydrogenase
3-hydroxybutyryl-CoA dehydrogenase
beta-ketoacyl-CoA reductase
beta-hydroxy acid dehydrogenase
3-L-hydroxyacyl-CoA dehydrogenase
3-hydroxyisobutyryl-CoA dehydrogenase
1-specific DPN-linked beta-hydroxybutyric dehydrogenase
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + (3S)-3-Hydroxyacyl-CoA <-> NADH + H+ + 3-Oxoacyl-CoA
NAD+ + (S)-3-Hydroxybutanoyl-CoA <-> NADH + H+ + Acetoacetyl-CoA
NADP+ + (S)-3-Hydroxybutanoyl-CoA <-> H+ + NADPH + Acetoacetyl-CoA
NAD+ + (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <-> NADH + H+ + 2-Methylacetoacetyl-CoA
NAD+ + (S)-3-Hydroxyhexadecanoyl-CoA <-> NADH + H+ + 3-Oxopalmitoyl-CoA
NAD+ + (S)-3-Hydroxytetradecanoyl-CoA <-> NADH + H+ + 3-Oxotetradecanoyl-CoA
NAD+ + (S)-3-Hydroxydodecanoyl-CoA <-> NADH + H+ + 3-Oxododecanoyl-CoA
NAD+ + (S)-3-Hydroxydecanoyl-CoA <-> NADH + H+ + 3-Oxodecanoyl-CoA
NAD+ + (S)-3-Hydroxyoctanoyl-CoA <-> NADH + H+ + 3-Oxooctanoyl-CoA
NAD+ + (S)-3-Hydroxyhexanoyl-CoA <-> NADH + H+ + 3-Oxohexanoyl-CoA
NAD+ + (S)-3-Hydroxyisobutyrate <-> NADH + H+ + (S)-Methylmalonate semialdehyde
NAD+ + (Hydroxymethylphenyl)succinyl-CoA <-> NADH + H+ + Benzoylsuccinyl-CoA
NADH + H+ + Acetoacetyl-S-pantetheine <-> NAD+ + (S)-3-Hydroxybutanoyl-S-pantetheine
NADH + H+ + S-(3-Oxobutyl)-CoA <-> NAD+ + 3-Hydroxybutyl-CoA
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.1.1.35



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