Enzyme Details

EC Classification

1.1.1.40

Enzyme name
(recommended)

malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

Alternative names

(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
'malic' enzyme
pyruvic-malic carboxylase
malate dehydrogenase (decarboxylating, NADP+)
NADP+-linked decarboxylating malic enzyme
NADP+-malic enzyme
NADP+-specific malic enzyme
NADP+-specific malate dehydrogenase
malate dehydrogenase (NADP+, decarboxylating)
L-malate:NADP+ oxidoreductase
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + L-Malate <-> Pyruvate + NADH + H+ + CO2

NADP+ + L-Malate <-> Pyruvate + H+ + NADPH + CO2

Oxaloacetate <-> Pyruvate + CO2

Pyruvate + H+ + NADPH <-> NADP+ + L-Lactate

Pyruvate + H+ + NADPH <-> NADP+ + Lactate

Bromopyruvate + Malic enzyme <-> Enzyme-ligand complex

NADPH + Malic enzyme <-> Enzyme-ligand complex

NADPH + Alkylated malic enzyme <-> Enzyme-ligand complex

Malic enzyme + 2',3'-Dialdehyde NADP+ <-> Enzyme-ligand complex

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.40