Enzyme Details

EC Classification

1.1.1.44

Enzyme name
(recommended)

phosphogluconate dehydrogenase (decarboxylating)

Alternative names

6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
phosphogluconic acid dehydrogenase
6-phosphogluconic dehydrogenase
6-phosphogluconic carboxylase
6-phosphogluconate dehydrogenase (decarboxylating)
6-phospho-D-gluconate dehydrogenase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NADP+ + 6-Phospho-D-gluconate <-> H+ + NADPH + CO2 + D-Ribulose 5-phosphate

NAD+ + 6-Phospho-D-gluconate <-> NADH + H+ + CO2 + D-Ribulose 5-phosphate

NADP+ + 2-Deoxy-6-phospho-D-gluconate <-> H+ + NADPH + 3-Keto-2-deoxy-6-phospho-D-gluconate

6-Phospho-D-gluconate + 3-Acetylpyridine adenine dinucleotide phosphate <-> H+ + CO2 + D-Ribulose 5-phosphate + Reduced 3-acetylpyridine adenine dinucleotide phosphate

6-Phospho-D-gluconate + Thionicotinamide adenine dinucleotide phosphate <-> H+ + CO2 + D-Ribulose 5-phosphate + Reduced thionicotinamide adenine dinucleotide phosphate

6-Phospho-D-gluconate + Nicotinamide 1,N6-ethenoadenine dinucleotide phosphate <-> H+ + CO2 + D-Ribulose 5-phosphate + Reduced nicotinamide 1,N6-ethenoadenine dinucleotide phosphate

6-Phospho-D-gluconate + Nicotinamide hypoxanthine dinucleotide phosphate <-> H+ + CO2 + D-Ribulose 5-phosphate + Reduced nicotinamide hypoxanthine dinucleotide phosphate

NADP+ + 2-Deoxy-6-phospho-D-gluconate <-> H+ + NADPH + CO2 + 2-Deoxy-D-ribulose 5-phosphate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.44