Enzyme Details

EC Classification

1.1.1.50

Enzyme name
(recommended)

3alpha-hydroxysteroid dehydrogenase (B-specific)

Alternative names

3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)
hydroxyprostaglandin dehydrogenase
3alpha-hydroxysteroid oxidoreductase
sterognost 3alpha

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NADP+ + trans-1,2-Dihydrobenzene-1,2-diol <-> H+ + NADPH + Catechol

H+ + NADPH + Progesterone <-> NADP+ + 5beta-Pregnane-3,20-dione

NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

NADP+ + Indan-1-ol <-> H+ + NADPH + Indanone

NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione

NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione

NAD+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha-Hydroxy-5beta-cholestan-3-one

NADP+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha-Hydroxy-5beta-cholestan-3-one

NAD+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

NAD+ + Urocortisol <-> NADH + H+ + 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione

NADP+ + Urocortisol <-> H+ + NADPH + 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione

NAD+ + 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al <-> NADH + H+ + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al

NADP+ + 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al <-> H+ + NADPH + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al

NAD+ + Tetrahydrocorticosterone <-> NADH + H+ + 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione

NADP+ + Tetrahydrocorticosterone <-> H+ + NADPH + 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione

NAD+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione <-> NADH + H+ + 21-Hydroxy-5beta-pregnane-3,11,20-trione

NADP+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione <-> H+ + NADPH + 21-Hydroxy-5beta-pregnane-3,11,20-trione

NAD+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione

NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione

H+ + NADPH + 1,4-Benzoquinone <-> NADP+ + Hydroquinone

NADP+ + 3beta-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione

NADP+ + Acenaphthen-1-ol <-> H+ + NADPH + 1-Acenaphthenone

NADP+ + Benzene dihydrodiol <-> H+ + NADPH + Catechol

H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol

H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol

H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol

NADP+ + 1,2-Dihydronaphthalene-1,2-diol <-> H+ + NADPH + Naphthalene-1,2-diol

H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol

NADP+ + (R)-Indan-1-ol <-> H+ + NADPH + Indanone

NADP+ + (S)-Indan-1-ol <-> H+ + NADPH + Indanone

H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol

H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin

H+ + NADPH + 2-Nitrobenzaldehyde <-> NADP+ + 2-Nitrobenzyl alcohol

H+ + NADPH + 4-Benzoylpyridine <-> Unknown + NADP+

H+ + NADPH + Menadione <-> NADP+ + Menadiol

NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <-> H+ + NADPH + 3-Oxocholic acid

NADP+ + Chenodeoxycholate <-> H+ + NADPH + 3alpha-Hydroxy-7-oxo-5beta-cholanate

NADP+ + 3alpha,12alpha-Dihydroxy-5beta-cholanate <-> H+ + NADPH + 12alpha-Hydroxy-3-oxo-5beta-cholanate

H+ + NADPH + Duroquinone <-> NADP+ + Duroquinol

NADH + H+ + p-Nitrobenzaldehyde <-> NAD+ + p-Nitrobenzyl alcohol

H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + Androstanediol

NADH + H+ + 9,10-Phenanthroquinone <-> NAD+ + Phenanthrene-9,10-diol

NADH + H+ + 4-Nitroacetophenone <-> NAD+ + 1-(4-Nitrophenyl)ethanol

H+ + NADPH + 3-Oxo-5beta-cholanate <-> NADP+ + 3alpha-Hydroxy-5beta-cholanate

H+ + NADPH + Camphorquinone <-> Unknown + NADP+

NADP+ + Benzene dihydrodiol <-> H+ + NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one

NADP+ + Ursodiol <-> H+ + NADPH + 7alpha,12alpha-dihydroxy-5beta-cholan-3-one-24-oic acid

NADP+ + 1,2,3,4-Tetrahydronaphth-1-ol <-> H+ + NADPH + alpha-Tetralone

H+ + NADPH + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NADP+ + Pregnanediol

NAD+ + Acenaphthen-1-ol <-> NADH + H+ + 1-Acenaphthenone

NAD+ + Benzene dihydrodiol <-> NADH + H+ + Catechol

H+ + NADPH + 1,4-Naphthoquinone <-> NADP+ + 1,4-Dihydronaphthalen-4-ol-1-one

H+ + NADPH + Acetophenone <-> NADP+ + Acenaphthen-1-ol

H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NADP+ + Tetrahydrocortisone

NADH + H+ + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NAD+ + Tetrahydrocortisone

NADP+ + 5beta-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5beta-Pregnan-21-ol-3,20-dione

NADP+ + Glycolithocholate <-> H+ + NADPH + 3-Oxo-5beta-glycocholanate

H+ + NADPH + 5alpha-Pregnane-2,20-dione <-> Unknown + NADP+

2 H+ + 2 NADPH + Acenaphthenequinone <-> 2 NADP+ + Acenaphthene-1,2-diol

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 3beta-Androstanediol

H+ + NADPH + 2,3-Heptanedione <-> NADP+ + 3-Hydroxyheptan-2-one

H+ + NADPH + 2,3-Hexanedione <-> NADP+ + 3-Hydroxyhexan-2-one

H+ + NADPH + 1-Phenyl-1,2-propanedione <-> Unknown + NADP+

H+ + NADPH + 2,3-Pentanedione <-> NADP+ + 3-Hydroxypentan-2-one

H+ + NADPH + Pyridine-4-aldehyde <-> NADP+ + 4-Pyridinemethanol

NAD+ + 3alpha,12alpha-Dihydroxy-5beta-cholanate <-> NADH + H+ + 12alpha-Hydroxy-3-oxo-5beta-cholanate

5alpha-Androstane-3alpha-ol-17-one + thio-NAD+ <-> H+ + 5alpha-Androstane-3,17-dione + thio-NADH

3alpha,12alpha-Dihydroxy-5beta-cholanate + thio-NAD+ <-> H+ + thio-NADH + 12alpha-Hydroxy-3-oxo-5beta-cholanate

NADP+ + 3alpha-Hydroxy-5alpha-pregnan-20-one <-> H+ + NADPH + 5alpha-Pregnane-3,20-dione

NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol

NAD+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <-> NADH + H+ + 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate

NAD+ + Fusidic acid <-> NADH + H+ + 3-Keto Fusidic Acid

NADH + H+ + Metyrapone <-> NAD+ + 2-Methyl-1,2-bis(3-pyridyl)-1-propanol

NADH + H+ + 2-(1-Imidazolyl)-1-(4-methoxyphenyl)-2-methyl-1-propanone <-> NAD+ + 1-(4-Methoxyphenyl)-2-methyl-2-(1H-imidazol-1-yl)-1-propanol

NAD+ + 5alpha-Androstane-3beta-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NADH + H+ + 5beta-Androstane-17beta-ol-3-one <-> NAD+ + 5beta-Androstane-3alpha,17beta-diol

NADH + H+ + 5alpha-Pregnanolone <-> NAD+ + 5alpha-Pregnanediol

NADH + H+ + 5beta-Pregnanolone <-> NAD+ + 5beta-Pregnanediol

NADH + H+ + 3-Dehydroecdysone <-> NAD+ + Ecdysone

NAD+ + Epiandrosterone <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NAD+ + Androstanediol <-> NADH + H+ + 5alpha-Androstane-17beta-ol-3-one

NAD+ + 3alpha-Hydroxy Desogestrel <-> NADH + H+ + Etonogestrel

NAD+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <-> NADH + H+ + 3-Oxocholic acid

NADH + H+ + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NAD+ + 5beta-Pregnanediol

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.50