Enzyme Details

EC Classification

1.1.1.87

Enzyme name
(recommended)

homoisocitrate dehydrogenase

Alternative names

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
2-hydroxy-3-carboxyadipate dehydrogenase
3-carboxy-2-hydroxyadipate dehydrogenase
homoisocitric dehydrogenase
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)
HICDH

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + Homoisocitrate <-> NADH + H+ + CO2 + 2-Oxoadipate

Oxaloglutarate <-> CO2 + 2-Oxoadipate

NAD+ + Homoisocitrate <-> NADH + H+ + Oxaloglutarate

NADP+ + Mannitol <-> H+ + NADPH + D-Fructose

NAD+ + Isocitrate <-> NADH + H+ + CO2 + 2-Oxoglutarate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.87