Enzyme Details

EC Classification

1.1.1.88

Enzyme name
(recommended)

hydroxymethylglutaryl-CoA reductase

Alternative names

(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
beta-hydroxy-beta-methylglutaryl coenzyme A reductase
beta-hydroxy-beta-methylglutaryl CoA-reductase
3-hydroxy-3-methylglutaryl coenzyme A reductase
hydroxymethylglutaryl coenzyme A reductase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

2 NAD+ + Coenzyme A + (S)-Mevalonate <-> 2 NADH + H+ + 3-Hydroxy-3-methylglutaryl-CoA

NAD+ + (R)-Mevalonate <-> NADH + H+ + Mevaldate

2 NAD+ + Coenzyme A + Mevalonate <-> 2 NADH + 2 H+ + 3-Hydroxy-3-methylglutaryl-CoA

NAD+ + Coenzyme A + Mevaldate <-> NADH + H+ + 3-Hydroxy-3-methylglutaryl-CoA

NADH + H+ + Mevaldate <-> NAD+ + Mevalonate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.88