Enzyme Details

EC Classification

1.13.11.31

Enzyme name
(recommended)

arachidonate 12-lipoxygenase

Alternative names

arachidonate:oxygen 12-oxidoreductase
Delta12-lipoxygenase
12-lipoxygenase
12Delta-lipoxygenase
C-12 lipoxygenase
12S-lipoxygenase
leukotriene A4 synthase
LTA4 synthase

Classification

Oxidoreductases

Acting on single donors with incorporation of molecular oxygen

With incorporation of two atoms of oxygen

Catalyses reactions

O2 + Arachidonate <-> 12-HPETE

O2 + Eicosapentaenoic acid <-> (5Z,8Z,10E,14Z,17Z)-(12S)-12-Hydroperoxyeicosapentaenoic acid

O2 + 8,11,14-Eicosatrienoate <-> (8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-8,10,14-trienoate

O2 + Arachidonate <-> H2O + Leukotriene A4

O2 + Linoleate <-> (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoate

2 H2O + O2 + 2 Leukotriene A4 <-> Lipoxin

H2O + O2 + 5,6-EET <-> 5,6-Epoxy-12-hydroxyeicosatrienoic acid

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.13.11.31