Enzyme Details

EC Classification

1.13.11.34

Enzyme name
(recommended)

arachidonate 5-lipoxygenase

Alternative names

arachidonate:oxygen 5-oxidoreductase
leukotriene-A4 synthase
Delta5-lipoxygenase
5Delta-lipoxygenase
arachidonic 5-lipoxygenase
arachidonic acid 5-lipoxygenase
C-5-lipoxygenase
LTA synthase
leukotriene A4 synthase

Classification

Oxidoreductases

Acting on single donors with incorporation of molecular oxygen

With incorporation of two atoms of oxygen

Catalyses reactions

O2 + Arachidonate <-> 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate

5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate <-> H2O + Leukotriene A4

O2 + Eicosapentaenoic acid <-> 5-Hydroperoxy-6,8,11,14,17-eicosapentaenoate

O2 + Arachidonate <-> H2O + Leukotriene A4

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.13.11.34