Enzyme Details

EC Classification

1.14.13

Enzyme name
(recommended)

With NADH or NADPH as one donor, and incorporation of one atom of oxygen

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalyses reactions

H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + Cholesterol-5alpha,6beta-epoxide

H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + Cholesterol-5beta,6beta-epoxide

H+ + NADPH + O2 + Androst-4-ene-3,17-dione <-> H2O + NADP+ + 19-Hydroxyandrost-4-ene-3,17-dione

NADH + H+ + O2 + Estrone <-> NAD+ + H2O + 2-Hydroxyestrone

H+ + NADPH + O2 + Estrone <-> H2O + NADP+ + 2-Hydroxyestrone

H+ + NADPH + O2 + Estrone <-> H2O + NADP+ + 16alpha-Hydroxyestrone

NADH + H+ + O2 + Tyramine <-> NAD+ + H2O + Dopamine

H+ + NADPH + O2 + Testosterone <-> H2O + NADP+ + 19-Hydroxytestosterone

NADH + H+ + O2 + Estradiol-17beta <-> NAD+ + H2O + 2-Hydroxyestradiol-17beta

H+ + NADPH + O2 + Estradiol-17beta <-> H2O + NADP+ + Estriol

H+ + NADPH + O2 + Estradiol-17beta <-> H2O + NADP+ + 2-Hydroxyestradiol-17beta

H+ + NADPH + O2 + Ferulate <-> H2O + NADP+ + 5-Hydroxyferulate

H+ + NADPH + O2 + Indolelactate <-> H2O + NADP+ + 6-Hydroxyindolelactate

beta-Carotene <-> Zeaxanthin

H+ + NADPH + O2 + 5-Cholestene <-> H2O + NADP+ + 5,6beta-Epoxy-5beta-cholestane

H+ + NADPH + 5-Cholestene <-> H2O + NADP+ + 5,6beta-Epoxy-5alpha-cholestane

H+ + NADPH + O2 + 7alpha-Hydroxycholest-4-en-3-one <-> H2O + NADP+ + 7alpha,12alpha-Dihydroxycholest-4-en-3-one

H+ + NADPH + O2 + 2-Hexaprenylphenol <-> H2O + NADP+ + 2-Hexaprenyl-6-hydroxyphenol

H+ + NADPH + O2 + 2-Hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone <-> H2O + NADP+ + 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone

H+ + NADPH + O2 + 2-Octaprenyl-6-methoxyphenol <-> H2O + NADP+ + 2-Octaprenyl-6-methoxy-1,4-benzoquinone

2-Hydroxyphenylacetate <-> 2,6-Dihydroxyphenylacetate

H2O + NADP+ + Nitrite + 1,4-Benzoquinone <-> H+ + NADPH + O2 + p-Nitrophenol

NADH + H+ + O2 + Toluene-4-sulfonate <-> NAD+ + H2O + 4-Sulfobenzyl alcohol

NADH + H+ + O2 + p-Xylene <-> NAD+ + H2O + alpha-Hydroxy-p-xylene

NADH + H+ + O2 + o-Xylene <-> NAD+ + H2O + 2-Methylbenzyl alcohol

NADH + H+ + O2 + m-Xylene <-> NAD+ + H2O + 3-Methylbenzyl alcohol

2 NADH + H+ + O2 + 2,5-Dichlorohydroquinone <-> Cl- + 2 NAD+ + OH- + 5-Chloro-1,2,4-trihydroxybenzene

2 NADH + H+ + O2 + 2,4,5-Trichlorophenol <-> Cl- + 2 NAD+ + OH- + 2,5-Dichlorohydroquinone

NADH + H+ + O2 + 2,6-Dichlorophenol <-> NAD+ + H2O + 2,6-Dichlorohydroquinone

2 NADH + H+ + O2 + 2,4,6-Trichlorophenol <-> Cl- + 2 NAD+ + OH- + 2,6-Dichlorohydroquinone

NADH + H+ + O2 + 2-Hydroxyphenylacetate <-> NAD+ + H2O + Homogentisate

NADH + H+ + O2 + Phenylacetic acid <-> NAD+ + H2O + 2-Hydroxyphenylacetate

H+ + NADPH + O2 + FAD + Styrene <-> H2O + NADP+ + FADH2 + Styrene oxide

NADH + H+ + O2 + Trimethylamine <-> NAD+ + H2O + Trimethylamine N-oxide

NADH + H+ + O2 + Phenanthracene <-> NAD+ + H2O + Phenanthrene-9,10-oxide

NADH + H+ + O2 + Phenanthracene <-> NAD+ + H2O + Phenanthrene-1,2-oxide

NADH + H+ + O2 + Phenanthracene <-> NAD+ + H2O + 1-Phenanthrol

NAD+ + Reduced FMN <-> NADH + H+ + Riboflavin-5-phosphate

H+ + NADPH + O2 + 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone <-> H2O + NADP+ + 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone

NADH + H+ + O2 + (+)-Limonene <-> NAD+ + OH- + Limonene-1,2-epoxide

H+ + NADPH + O2 + (1S,4R)-1-Hydroxy-2-oxolimonene <-> OH- + NADP+ + (3R)-3-Isopropenyl-6-oxoheptanoate

NADH + H+ + O2 + alpha-Pinene <-> NAD+ + H2O + alpha-Pinene-oxide

H+ + NADPH + O2 + Coniferaldehyde <-> H2O + NADP+ + 5-Hydroxyconiferaldehyde

H+ + NADPH + O2 + Coniferyl alcohol <-> H2O + NADP+ + 5-Hydroxyconiferyl alcohol

Tetracenomycin A2 <-> Tetracenomycin C

NADH + H+ + O2 + 3-(3-Hydroxy-phenyl)-propanoic acid <-> NAD+ + H2O + 3-(2,3-Dihydroxyphenyl)propanoate

NADH + H+ + O2 + trans-3-Hydroxycinnamate <-> NAD+ + H2O + trans-2,3-Dihydroxycinnamate

H+ + NADPH + O2 + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide <-> H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide

NADH + H+ + FAD <-> NAD+ + FADH2

NADH + H+ + Riboflavin <-> NAD+ + Reduced riboflavin

H+ + NADPH + O2 + Chlorzoxazone <-> H2O + NADP+ + 6-Hydroxy-chlorzoxazone

NADH + H+ + O2 + FAD + Styrene <-> NAD+ + H2O + FADH2 + (S)-Styrene oxide

NADPH + O2 + Campesterol <-> H2O + NADP+ + 22alpha-Hydroxy-campesterol

NADPH + O2 + Campestanol <-> H2O + NADP+ + 6-Deoxocathasterone

H+ + NADPH + O2 + 4-Hydroxybenzoate <-> H2O + NADP+ + 2,5-Dihydroxybenzoate

H+ + NADPH + O2 + Ethionamide <-> H2O + NADP+ + Ethionamide-S-oxide

NADPH + O2 + N-Nitrosodimethylamine <-> H2O + NADP+ + Formaldehyde + N-Nitrosomethylamine

H+ + NADPH + O2 + Mephenytoin <-> H2O + NADP+ + 4-Hydroxymephenytoin

H+ + NADPH + O2 + Retinoate <-> H2O + NADP+ + 4-Hydroxyretinoic acid

H+ + NADPH + O2 + Retinoate <-> H2O + NADP+ + 18-Hydroxyretinoic acid

H+ + NADPH + O2 + Retinoate <-> H2O + NADP+ + 3-Hydroxyretinoic acid

H+ + NADPH + O2 + Retinoate <-> Unknown + H2O + NADP+

NADPH + O2 + 9-cis-Retinoic acid <-> H+ + H2O + NADP+ + 9-cis-4-Hydroxyretinoic acid

NADPH + O2 + Tazarotenic acid <-> H+ + H2O + NADP+ + Tazarotenic acid sulfoxide

NADPH + O2 + Tazarotenic acid <-> H+ + H2O + NADP+ + Hydroxytazarotenic acid

H+ + NADPH + O2 + Isopentenyladenine riboside monophosphate <-> H2O + NADP+ + 9-Ribosyl-trans-zeatin 5'-monophosphate

H+ + NADPH + O2 + Isopentenyladenine riboside diphosphate <-> H2O + NADP+ + 9-Ribosyl-trans-zeatin 5'-diphosphate

H+ + NADPH + O2 + Isopentenyladenine riboside triphosphate <-> H2O + NADP+ + 9-Ribosyl-trans-zeatin 5'-triphosphate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.13