Enzyme Details

EC Classification

1.14.13.7

Enzyme name
(recommended)

phenol 2-monooxygenase

Alternative names

phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)
phenol hydroxylase
phenol o-hydroxylase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalyses reactions

2 NADH + 2 H+ + O2 <-> 2 NAD+ + 2 H2O

H+ + NADPH + O2 + Phenol <-> H2O + NADP+ + Catechol

H+ + NADPH + O2 + Toluene <-> H2O + NADP+ + o-Cresol

H+ + NADPH + O2 + Toluene <-> H2O + NADP+ + 3-Cresol

H+ + NADPH + O2 + 3-Cresol <-> H2O + NADP+ + 2,3-Dihydroxytoluene

H+ + NADPH + O2 + 4-Cresol <-> H2O + NADP+ + 2,3-Dihydroxytoluene

H+ + NADPH + O2 + o-Cresol <-> H2O + NADP+ + 2,3-Dihydroxytoluene

H+ + NADPH + O2 + Resorcinol <-> H2O + NADP+ + Benzene-1,2,4-triol

NAD+ + Reduced FMN <-> NADH + H+ + Riboflavin-5-phosphate

H+ + NADPH + O2 + Hydroquinone <-> H2O + NADP+ + Benzene-1,2,4-triol

NADH + H+ + 2,6-Dichloroindophenol <-> NAD+ + Reduced 2,6-dichlorophenolindophenol

NADH + H+ + 3-Acetylpyridine-adenine dinucleotide <-> NAD+ + Reduced 3-acetylpyridine-adenine dinucleotide

NADH + H+ + FAD <-> NAD+ + FADH2

NADH + H+ + Riboflavin <-> NAD+ + Reduced riboflavin

H+ + NADPH + FAD <-> NADP+ + FADH2

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.13.7

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