Enzyme Details

EC Classification

1.14.13.8

Enzyme name
(recommended)

flavin-containing monooxygenase

Alternative names

N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)
dimethylaniline oxidase
dimethylaniline N-oxidase
FAD-containing monooxygenase
N,N-dimethylaniline monooxygenase
DMA oxidase
flavin mixed function oxidase
Ziegler's enzyme
mixed-function amine oxidase
FMO
FMO-I
FMO-II
FMO1
FMO2
FMO3
FMO4
FMO5
flavin monooxygenase
methylphenyltetrahydropyridine N-monooxygenase
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase
dimethylaniline monooxygenase (N-oxide-forming)

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalyses reactions

H+ + NADPH + O2 + N,N-Dimethylaniline <-> H2O + NADP+ + N,N-Dimethylaniline N-oxide

H+ + NADPH + O2 + L-Selenomethionine <-> H2O + NADP+ + L-Selenomethionine selenoxide

H+ + L-Methionine + NADPH + O2 <-> H2O + NADP+ + L-Methionine S-oxide

H+ + NADPH + O2 + S-Benzyl-L-cysteine <-> H2O + NADP+ + S-Benzyl-L-cysteine S-oxide

H+ + NADPH + O2 + Methimazole <-> H2O + NADP+ + Methimazole S-oxide

H+ + NADPH + O2 + Trimethylamine <-> H2O + NADP+ + Trimethylamine N-oxide

H+ + NADPH + O2 + Benzydamine <-> H2O + NADP+ + Benzydamine N-oxide

NADPH + O2 + Methyl 4-tolyl sulfide <-> H2O + NADP+ + Methyl 4-tolyl sulfoxide

H+ + NADPH + O2 + Ethylenethiourea <-> H2O + NADP+ + Ethylenethiourea S-oxide

H+ + NADPH + O2 + Sulindac <-> H2O + NADP+ + Sulindac S-oxide

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.13.8