Enzyme Details
EC Classification
1.14.14.154
Enzyme name
(recommended)
sterol 14alpha-demethylase
Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Catalyses reactions
3 H+ + 3 NADPH + 3 O2 + Lanosterol <-> 4 H2O + 3 NADP+ + Formate + 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
3 H+ + 3 NADPH + 3 O2 + 24,25-Dihydrolanosterol <-> 4 H2O + 3 NADP+ + Formate + 4,4-Dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
Ketoconazole + CYP51m <-> Enzyme-inhibitor complex
Itraconazole + CYP51m <-> Enzyme-inhibitor complex
Fluconazole + CYP51m <-> Enzyme-inhibitor complex
3 H+ + 3 NADPH + 3 O2 + Eburicol <-> 4 H2O + 3 NADP+ + Formate + 14-Demethyleburicol
3 H+ + 3 NADPH + 3 O2 + Obtusifoliol <-> 4 H2O + 3 NADP+ + Formate + 4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
Eburicol + CYP51B <-> Enzyme-ligand complex
Obtusifoliol + CYP51B <-> Enzyme-ligand complex
CYP51B + (R)-N-(1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide <-> Enzyme-inhibitor complex
Voriconazole + CYP51B <-> Enzyme-inhibitor complex
Lanosterol + CYP51 <-> Enzyme-ligand complex
Eburicol + CYP51 <-> Enzyme-ligand complex
Obtusifoliol + CYP51 <-> Enzyme-ligand complex
CYP51 + 31-Norlanosterol <-> Enzyme-ligand complex
CYP51 + Posaconazole <-> Enzyme-inhibitor complex
CYP51 + Oteseconazole <-> Enzyme-inhibitor complex
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
1.14.14.154
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