Enzyme Details

EC Classification

1.14.14.19

Enzyme name
(recommended)

steroid 17alpha-monooxygenase

Alternative names

steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
steroid 17alpha-hydroxylase
cytochrome P-45017alpha
cytochrome P-450 (P-45017alpha,lyase)
17alpha-hydroxylase-C17,20 lyase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Catalyses reactions

O2 + Reduced acceptor + Steroid <-> H2O + Acceptor + 17-alpha-Hydroxysteroid

O2 + Reduced acceptor + Progesterone <-> H2O + Acceptor + 17alpha-Hydroxyprogesterone

O2 + Reduced acceptor + Pregnenolone <-> H2O + Acceptor + 17alpha-Hydroxypregnenolone

H2O + Acceptor + 21-Deoxycortisol <-> O2 + Reduced acceptor + 11beta-Hydroxyprogesterone

H+ + NADPH + O2 + 20alpha-Hydroxycholesterol <-> H2O + NADP+ + 17alpha,20alpha-Dihydroxycholesterol

H+ + NADPH + 17alpha-Hydroxypregnenolone <-> NADP+ + 3beta-Hydroxyandrost-5-en-17-one

H+ + NADPH + 17alpha-Hydroxyprogesterone <-> NADP+ + Androst-4-ene-3,17-dione

H+ + NADPH + O2 + Progesterone <-> H2O + NADP+ + 17alpha-Hydroxyprogesterone

H+ + NADPH + O2 + Pregnenolone <-> H2O + NADP+ + 17alpha-Hydroxypregnenolone

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.14.19