Enzyme Details

EC Classification

1.14.14.91

Enzyme name
(recommended)

trans-cinnamate 4-monooxygenase

Alternative names

trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)
cinnamic acid 4-hydroxylase
oxygenase, cinnamate 4-mono-
CA4H
cytochrome P450 cinnamate 4-hydroxylase
cinnamate 4-hydroxylase
cinnamate 4-monooxygenase
cinnamate hydroxylase
cinnamic 4-hydroxylase
cinnamic acid 4-monooxygenase
cinnamic acid p-hydroxylase
hydroxylase, cinnamate 4-
t-cinnamic acid hydroxylase
trans-cinnamate 4-hydroxylase
trans-cinnamic acid 4-hydroxylase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Catalyses reactions

H+ + NADPH + O2 + trans-Cinnamate <-> H2O + NADP+ + 4-Coumarate

H+ + NADPH + O2 + trans-Cinnamate <-> H2O + NADP+ + 2-Hydroxycinnamate

H+ + NADPH + O2 + 2-Fluoro-trans-cinnamate <-> H2O + NADP+ + 2-Fluoro-4-hydroxycinnamate

H+ + NADPH + O2 + 2-Chloro-trans-cinnamate <-> H2O + NADP+ + 2-Chloro-4-hydroxycinnamate

H+ + NADPH + O2 + 3-Hydroxycinnamate <-> H2O + NADP+ + Caffeate

H+ + NADPH + O2 + 2-Methylcinnamate <-> H2O + NADP+ + 2-Methyl-4-hydroxycinnamate

H+ + NADPH + O2 + 2-Ethoxycinnamate <-> H2O + NADP+ + 2-Ethoxy-4-hydroxycinnamate