Enzyme Details

 EC Classification 1.14.14.94
 Enzyme name
(recommended)
leukotriene-B4 20-monooxygenase
 Alternative names (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
leukotriene-B4 20-hydroxylase
leucotriene-B4 omega-hydroxylase
LTB4 20-hydroxylase
LTB4 omega-hydroxylase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
 Catalyses reactions
H+ + NADPH + O2 + Leukotriene B4 <-> H2O + NADP+ + 20-OH-Leukotriene B4
NADH + H+ + O2 + Leukotriene B4 <-> NAD+ + H2O + 19-OH-Leukotriene B4
NADH + H+ + O2 + Leukotriene B4 <-> NAD+ + H2O + 20-OH-Leukotriene B4
H+ + NADPH + O2 + Leukotriene B4 <-> H2O + NADP+ + 19-OH-Leukotriene B4
H+ + NADPH + O2 + 20-CHO-Leukotriene B4 <-> H2O + NADP+ + 20-COOH-Leukotriene B4
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.14.14.94



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