Enzyme Details

EC Classification

1.14.15.15

Enzyme name
(recommended)

cholestanetriol 26-monooxygenase

Alternative names

5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)
5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase
5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase
cholestanetriol 26-hydroxylase
sterol 27-hydroxylase
sterol 26-hydroxylase
cholesterol 27-hydroxylase
CYP27A
CYP27A1
cytochrome P450 27A1'

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

Catalyses reactions

H+ + NADPH + O2 + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H2O + NADP+ + 3alpha,7alpha,26-Trihydroxy-5beta-cholestane

H+ + NADPH + O2 + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> H2O + NADP+ + 3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane

H+ + NADPH + O2 + 3alpha-O-Succinyl-5beta-cholestane-7alpha,12alpha-diol <-> H2O + NADP+ + 3alpha-O-Succinyl-5beta-cholestane-7alpha,12alpha,26-triol

H+ + NADPH + O2 + 5beta-Cholestane-3alpha-ol <-> H2O + NADP+ + 5beta-Cholestane-3alpha,26-diol

H+ + NADPH + O2 + Vitamin D3 <-> H2O + NADP+ + Calcidiol

H+ + NADPH + O2 + 1alpha-Hydroxyvitamin D3 <-> H2O + NADP+ + Calcitriol

H+ + NADPH + O2 + 1-alpha-Hydroxyvitamin D2 <-> H2O + NADP+ + 1-alpha, 25-Dihydroxyvitamin D2

H+ + NADPH + O2 + Calcidiol <-> H2O + NADP+ + Dihydroxyvitamin D3

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.15.15