Enzyme Details

EC Classification

1.14.15.4

Enzyme name
(recommended)

steroid 11beta-monooxygenase

Alternative names

steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
steroid 11beta-hydroxylase
steroid 11beta/18-hydroxylase
oxygenase, steroid 11beta -mono-

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

Catalyses reactions

O2 + Reduced ferredoxin + Progesterone <-> H2O + Oxidized ferredoxin + 11beta-Hydroxyprogesterone

O2 + Reduced adrenal ferredoxin + Androst-4-ene-3,17-dione <-> H2O + Oxidized adrenal ferredoxin + 11beta-Hydroxyandrost-4-ene-3,17-dione

O2 + Reduced adrenal ferredoxin + Steroid <-> H2O + Oxidized adrenal ferredoxin + 11beta-Hydroxysteroid

O2 + Reduced ferredoxin + 11-Deoxycortisol <-> H2O + Oxidized ferredoxin + Cortisol

H+ + NADPH + O2 + 17alpha-Hydroxyprogesterone <-> H2O + NADP+ + 21-Deoxycortisol

O2 + Reduced ferredoxin + 11-Deoxycorticosterone <-> H2O + Oxidized ferredoxin + Corticosterone

H+ + NADPH + O2 + 17alpha,21-Dihydroxypregnenolone <-> H2O + NADP+ + 11beta,17alpha,21-Trihydroxypregnenolone

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.15.4