Enzyme Details

 EC Classification 1.14.20.1
 Enzyme name
(recommended)		 deacetoxycephalosporin-C synthase
 Alternative names penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)
DAOCS
penicillin N expandase
DAOC synthase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With 2-oxoglutarate as one donor, and the other dehydrogenated
 Catalyses reactions
H2O + 2 CO2 + 2 Succinate + Deacetylcephalosporin C <-> 2 O2 + 2 2-Oxoglutarate + Penicillin N
O2 + 2-Oxoglutarate + Penicillin N <-> H2O + CO2 + Succinate + Deacetoxycephalosporin C
O2 + 2-Oxoglutarate + Penicillin G <-> H2O + CO2 + Succinate + Phenylacetyl-7-aminodeacetoxy cephalosporanic acid
O2 + 4-Methyl-2-oxopentanoate + Penicillin G <-> H2O + CO2 + Isovaleric acid + Phenylacetyl-7-aminodeacetoxy cephalosporanic acid
O2 + 2-Oxohexanoate + Penicillin G <-> H2O + CO2 + Pentanoate + Phenylacetyl-7-aminodeacetoxy cephalosporanic acid
O2 + 4-Methyl-2-oxopentanoate + Ampicillin <-> H2O + CO2 + Cephalexin + Isovaleric acid
O2 + 2-Oxohexanoate + Ampicillin <-> H2O + CO2 + Pentanoate + Cephalexin
O2 + 2-Oxoglutarate + Ampicillin <-> H2O + CO2 + Succinate + Cephalexin
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.14.20.1



© HITS gGmbH