Enzyme Details

EC Classification

1.17.4.1

Enzyme name
(recommended)

ribonucleoside-diphosphate reductase

Alternative names

2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
ribonucleotide reductase
CDP reductase
ribonucleoside diphosphate reductase
UDP reductase
ADP reductase
nucleoside diphosphate reductase
ribonucleoside 5'-diphosphate reductase
ribonucleotide diphosphate reductase
2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
RR

Classification

Oxidoreductases

Acting on -CH(2) groups

With a disulfide as acceptor

Catalyses reactions

H2O + Oxidized thioredoxin + dGDP <-> GDP + Reduced thioredoxin

H2O + dADP + Oxidized thioredoxin <-> ADP + Reduced thioredoxin

H2O + Oxidized thioredoxin + dUDP <-> UDP + Reduced thioredoxin

H2O + Oxidized thioredoxin + dCDP <-> CDP + Reduced thioredoxin

H2O + Oxidized thioredoxin + Deoxynucleoside diphosphate <-> Reduced thioredoxin + NDP

CDP + Reduced glutaredoxin <-> H2O + dCDP + Oxidized glutaredoxin

CDP + 1,4-Dithiothreitol <-> H2O + dCDP + Oxidized dithiothreitol

CTP + 1,4-Dithiothreitol <-> H2O + dCTP + Oxidized dithiothreitol

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.17.4.1