Enzyme Details
EC Classification
1.2.1.23
Enzyme name
(recommended)
2-oxoaldehyde dehydrogenase (NAD+)
Alternative names
2-oxoaldehyde:NAD+ 2-oxidoreductase
alpha-ketoaldehyde dehydrogenase
methylglyoxal dehydrogenase
NAD+-linked alpha-ketoaldehyde dehydrogenase
2-ketoaldehyde dehydrogenase
NAD+-dependent alpha-ketoaldehyde dehydrogenase
2-oxoaldehyde dehydrogenase (NAD+)
Classification
Oxidoreductases
Acting on the aldehyde or oxo group of donors
With NAD(+) or NADP(+) as acceptor
Catalyses reactions
NAD+ + H2O + 2-Oxoaldehyde <-> NADH + H+ + 2-Oxo acid
NAD+ + H2O + Methylglyoxal <-> Pyruvate + NADH + H+
H2O + NADP+ + Methylglyoxal <-> Pyruvate + H+ + NADPH
NAD+ + H2O + D-Lactaldehyde <-> NADH + H+ + D-Lactate
NAD+ + H2O + Hydroxypyruvaldehyde <-> NADH + H+ + 3-Hydroxypyruvate
H2O + Methylglyoxal + 3-Acetylpyridine-adenine dinucleotide <-> Pyruvate + H+ + Reduced 3-acetylpyridine-adenine dinucleotide
NAD+ + H2O + Phenylglyoxal <-> NADH + H+ + alpha-Oxo-benzeneacetic acid
NAD+ + H2O + Glyoxal <-> NADH + H+ + Glyoxylate
H2O + Methylglyoxal + thio-NAD+ <-> Pyruvate + H+ + thio-NADH
NAD+ + H2O + 2-Keto-3-deoxy-D-glucose <-> NADH + H+ + 2-Keto-3-deoxy-D-gluconate
NAD+ + H2O + 3-Deoxy-D-glucosone <-> NADH + 2-Keto-3-deoxy-D-gluconate
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
1.2.1.23
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