Enzyme Details

 EC Classification 1.2.1.27
 Enzyme name
(recommended)		 methylmalonate-semialdehyde dehydrogenase (acylating)
 Alternative names 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
MSDH
MMSA dehydrogenase
 Classification
Oxidoreductases
Acting on the aldehyde or oxo group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + Coenzyme A + 3-Oxopropanoate <-> NADH + H+ + CO2 + Acetyl-CoA
NAD+ + Coenzyme A + 2-Methyl-3-oxopropanoate <-> NADH + H+ + CO2 + Propanoyl-CoA
NAD+ + Coenzyme A + (S)-Methylmalonate semialdehyde <-> NADH + H+ + CO2 + Propanoyl-CoA
NAD+ + H2O + 2-Methyl-3-oxopropanoate <-> NADH + H+ + CO2 + Propanoate
NAD+ + H2O + 3-Oxopropanoate <-> NADH + H+ + CO2 + Acetate
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.2.1.27



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