Enzyme Details

EC Classification

1.2.1.5

Enzyme name
(recommended)

aldehyde dehydrogenase [NAD(P)+]

Alternative names

aldehyde:NAD(P)+ oxidoreductase
aldehyde dehydrogenase [NAD(P)+]
ALDH

Classification

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

H2O + NADP+ + Acetaldehyde <-> H+ + NADPH + Acetate

NAD+ + H2O + Acetaldehyde <-> NADH + H+ + Acetate

NAD+ + H2O + L-Glutamate 5-semialdehyde <-> NADH + H+ + L-Glutamate

H2O + NADP+ + Aldehyde <-> H+ + NADPH + Acid

NAD+ + H2O + Benzaldehyde <-> NADH + H+ + Benzoate

H2O + NADP+ + Benzaldehyde <-> H+ + NADPH + Benzoate

NAD+ + H2O + 16-Hexadecanal <-> NADH + H+ + Palmitate

NAD+ + H2O + all-trans-Retinal <-> NADH + H+ + Retinoate

NAD+ + H2O + Phenylacetaldehyde <-> NADH + H+ + Phenylacetic acid

H2O + NADP+ + Phenylacetaldehyde <-> H+ + NADPH + Phenylacetic acid

NAD+ + H2O + Indole-3-acetaldehyde <-> NADH + H+ + Indole-3-acetate

NAD+ + H2O + 4-Hydroxyphenylacetaldehyde <-> NADH + H+ + 4-Hydroxyphenylacetate

H2O + NADP+ + 4-Hydroxyphenylacetaldehyde <-> H+ + NADPH + 4-Hydroxyphenylacetate

NAD+ + H2O + 3,4-Dihydroxyphenylacetaldehyde <-> NADH + H+ + 3,4-Dihydroxyphenylacetate

H2O + NADP+ + 3,4-Dihydroxyphenylacetaldehyde <-> H+ + NADPH + 3,4-Dihydroxyphenylacetate

NAD+ + H2O + 3,4-Dihydroxymandelaldehyde <-> NADH + H+ + 3,4-Dihydroxymandelate

H2O + NADP+ + 3,4-Dihydroxymandelaldehyde <-> H+ + NADPH + 3,4-Dihydroxymandelate

NAD+ + H2O + 3-Methoxy-4-hydroxyphenylacetaldehyde <-> NADH + H+ + Homovanillate

H2O + NADP+ + 3-Methoxy-4-hydroxyphenylacetaldehyde <-> H+ + NADPH + Homovanillate

NAD+ + H2O + 3-Methoxy-4-hydroxyphenylglycolaldehyde <-> NADH + H+ + 3-Methoxy-4-hydroxymandelate

H2O + NADP+ + 3-Methoxy-4-hydroxyphenylglycolaldehyde <-> H+ + NADPH + 3-Methoxy-4-hydroxymandelate

NAD+ + H2O + Methylimidazole acetaldehyde <-> NADH + H+ + Methylimidazoleacetic acid

NAD+ + H2O + Butanal <-> NADH + H+ + Butanoate

NAD+ + H2O + 1-Octanal <-> NADH + H+ + Octanoate

NAD+ + H2O + Decanal <-> NADH + H+ + Decanoate

NAD+ + H2O + Hexanal <-> NADH + H+ + Hexanoate

NAD+ + H2O + Heptanal <-> NADH + H+ + Heptanoate

H2O + NADP+ + Propanal <-> H+ + NADPH + Propanoate

NAD+ + H2O + 4-Methoxybenzaldehyde <-> NADH + H+ + 4-Methoxybenzoate

NAD+ + H2O + p-Nitrobenzaldehyde <-> NADH + H+ + p-Nitrobenzoate

NAD+ + H2O + trans-2-Hexenal <-> NADH + H+ + trans-2-Hexenoic acid

H2O + NADP+ + Malondialdehyde <-> H+ + NADPH + 3-Oxopropanoate

H2O + NADP+ + 4-Hydroxy-2-nonenal <-> H+ + NADPH + 4-Hydroxy-2-nonenoic acid

H2O + NADP+ + Dodecanal <-> H+ + NADPH + Dodecanoate

H2O + NADP+ + Decanal <-> H+ + NADPH + Decanoate

H2O + NADP+ + Glyceraldehyde <-> H+ + NADPH + Glycerate

H2O + NADP+ + Nonanal <-> H+ + NADPH + Nonanoate

H2O + NADP+ + trans-2-Hexenal <-> H+ + NADPH + trans-2-Hexenoic acid

H2O + NADP+ + trans-2-Octenal <-> H+ + NADPH + trans-2-Octenoic acid

H2O + NADP+ + trans-2-Nonenal <-> H+ + NADPH + trans-2-Nonenoic acid

H2O + NADP+ + 1-Octanal <-> H+ + NADPH + Octanoate

H2O + NADP+ + Hexanal <-> H+ + NADPH + Hexanoate

NAD+ + H2O + Propanal <-> NADH + H+ + Propanoate

H2O + NADP+ + Pyridine-4-aldehyde <-> H+ + NADPH + Isonicotinic acid

NAD+ + H2O + Aldophosphamide <-> NADH + H+ + 3-[Amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoate

H2O + NADP+ + Aldophosphamide <-> H+ + NADPH + 3-[Amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoate

NAD+ + H2O + Pyridine-4-aldehyde <-> NADH + H+ + Isonicotinic acid

H2O + Propanal + 3-Acetylpyridine-adenine dinucleotide <-> H+ + Propanoate + Reduced 3-acetylpyridine-adenine dinucleotide

H2O + Deamino-NAD+ + Propanal <-> H+ + Propanoate + Deamino-NADH

NAD+ + H2O + Formaldehyde <-> NADH + H+ + Formate

NAD+ + H2O + 2-Methylpropanal <-> NADH + H+ + Isobutanoate

NAD+ + H2O + Glyceraldehyde <-> NADH + H+ + Glycerate

NAD+ + H2O + Glutaral <-> NADH + H+ + 5-Oxopentanoate

NAD+ + H2O + Glycolaldehyde <-> NADH + H+ + Glycolate

NAD+ + H2O + m-Nitrobenzaldehyde <-> NADH + H+ + m-Nitrobenzoate

NAD+ + H2O + 2,4-Dihydroxybenzaldehyde <-> NADH + H+ + 2,4-Dihydroxybenzoate

NAD+ + H2O + Furfural <-> NADH + H+ + 2-Furoate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.2.1.5