Enzyme Details

 EC Classification 1.3.1.22
 Enzyme name
(recommended)
cholestenone 5alpha-reductase
 Alternative names 3-oxo-5alpha-steroid:NADP+ Delta4-oxidoreductase
testosterone Delta4-5alpha-reductase
steroid 5alpha-reductase
3-oxosteroid Delta4-dehydrogenase
5alpha-reductase
steroid 5alpha-hydrogenase
3-oxosteroid 5alpha-reductase
testosterone Delta4-hydrogenase
4-ene-3-oxosteroid 5alpha-reductase
reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase
4-ene-5alpha-reductase
Delta4-3-ketosteroid 5alpha-oxidoreductase
cholest-4-en-3-one 5alpha-reductase
testosterone 5alpha-reductase
 Classification
Oxidoreductases
Acting on the CH-CH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NADP+ + 5alpha-Pregnane-3,20-dione <-> H+ + NADPH + Progesterone
NADP+ + 5alpha-Cholestan-3-one <-> H+ + NADPH + Cholest-4-en-3-one
NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + Testosterone
H+ + NADPH + Corticosterone <-> NADP+ + 5alpha-Dihydrocorticosterone
H+ + NADPH + Cortisol <-> NADP+ + 11beta,17alpha,21-Trihydroxy-5alpha-pregnane-3,20-dione
H+ + NADPH + Androst-4-ene-3,17-dione <-> NADP+ + 5alpha-Androstane-3,17-dione
H+ + NADPH + Campest-4-en-3-one <-> NADP+ + 5alpha-Campestan-3-one
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.3.1.22



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