Enzyme Details
EC Classification
1.3.5.2
Enzyme name
(recommended)
dihydroorotate dehydrogenase (quinone)
Alternative names
(S)-dihydroorotate:quinone oxidoreductase
dihydroorotate:ubiquinone oxidoreductase
(S)-dihydroorotate:(acceptor) oxidoreductase
(S)-dihydroorotate:acceptor oxidoreductase
DHOdehase (ambiguous)
DHOD (ambiguous)
DHODase (ambiguous)
DHODH
Classification
Oxidoreductases
Acting on the CH-CH group of donors
With a quinone or related compound as acceptor
Catalyses reactions
O2 + L-Dihydroorotate <-> H2O2 + Orotate
L-Dihydroorotate + Acceptor <-> Orotate + Reduced acceptor
Fumarate + L-Dihydroorotate <-> Succinate + Orotate
L-Dihydroorotate + Ubiquinone <-> Orotate + Ubiquinol
L-Dihydroorotate + Decylubiquinone <-> Orotate + Decylubiquinol
L-Dihydroorotate + 2,6-Dichloroindophenol <-> Orotate + Reduced 2,6-dichlorophenolindophenol
L-Dihydroorotate + Menadione <-> Orotate + Menadiol
Ubiquinone + L-Dihydroorotate 6'-methylester <-> Ubiquinol + Orotate 6'-methylester
Ubiquinone + Benzyl-S-dihydroorotate <-> Ubiquinol + Benzyl-S-orotate
Ubiquinone + Methyl-S-dihydroorotate <-> Ubiquinol + Methyl-S-orotate
L-Dihydroorotate + Oxidized DHOD <-> Reduced DHOD-orotate complex
Reduced DHOD-orotate complex <-> Orotate + Reduced DHOD
L-Dihydroorotate + Reduced DHOD <-> Reduced DHOD-L-dihydroorotate complex
Orotate + Menadione + Reduced DHOD <-> Oxidized DHOD-orotate-menadiol complex
Menadione + Reduced DHOD <-> Oxidized DHOD-menadiol complex
O2 + Reduced DHOD <-> H2O2 + Oxidized DHOD
O2 + Orotate + Reduced DHOD <-> H2O2 + Oxidized DHOD-orotate complex
Hexacyanoferrate(III) + Reduced DHOD <-> Hexacyanoferrate(II) + Oxidized DHOD complex
Orotate + Hexacyanoferrate(III) + Reduced DHOD <-> Hexacyanoferrate(II) + Oxidized DHOD-orotate complex
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
1.3.5.2
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