Enzyme Details

EC Classification

1.3.8.4

Enzyme name
(recommended)

isovaleryl-CoA dehydrogenase

Alternative names

3-methylbutanoyl-CoA:acceptor oxidoreductase
isovaleryl-coenzyme A dehydrogenase
isovaleroyl-coenzyme A dehydrogenase
3-methylbutanoyl-CoA:(acceptor) oxidoreductase

Classification

Oxidoreductases

Acting on the CH-CH group of donors

With a flavin as acceptor

Catalyses reactions

FAD + Propanoyl-CoA <-> Acryloyl-CoA + FADH2

FAD + Butanoyl-CoA <-> Crotonoyl-CoA + FADH2

FAD + 2-Methylbutanoyl-CoA <-> FADH2 + 2-Methylbut-2-enoyl-CoA

FAD + Hexanoyl-CoA <-> FADH2 + trans-Hex-2-enoyl-CoA

FAD + Pentanoyl-CoA <-> FADH2 + trans-Pent-2-enoyl-CoA

FAD + 3-Methylbutanoyl-CoA <-> FADH2 + 3-Methylcrotonyl-CoA

3-Methylbutanoyl-CoA + Acceptor <-> 3-Methylcrotonyl-CoA + Reduced acceptor

3-Methylbutanoyl-CoA + Electron-transferring flavoprotein <-> CO2 + 3-Methylcrotonyl-CoA + Reduced electron-transferring flavoprotein

2-Methylpropanoyl-CoA + Electron-transferring flavoprotein <-> 2-Methylprop-2-enoyl-CoA + Reduced electron-transferring flavoprotein

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.3.8.4