Enzyme Details
EC Classification
1.3.8.7
Enzyme name
(recommended)
medium-chain-acyl-CoA dehydrogenase
Alternative names
medium-chain acyl-coenzyme A dehydrogenase
medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Classification
Oxidoreductases
Acting on the CH-CH group of donors
With a flavin as acceptor
Catalyses reactions
FAD + Propanoyl-CoA <-> Acryloyl-CoA + FADH2
FAD + Butanoyl-CoA <-> Crotonoyl-CoA + FADH2
Butanoyl-CoA + Acceptor <-> Crotonoyl-CoA + Reduced acceptor
FAD + 2-Methylpropanoyl-CoA <-> FADH2 + 2-Methylprop-2-enoyl-CoA
FAD + 2-Methylbutanoyl-CoA <-> FADH2 + 2-Methylbut-2-enoyl-CoA
FAD + Octanoyl-CoA <-> FADH2 + trans-Oct-2-enoyl-CoA
FAD + 3-Methylbutanoyl-CoA <-> FADH2 + 3-Methylcrotonyl-CoA
Propanoyl-CoA + Electron-transferring flavoprotein <-> Acryloyl-CoA + Reduced electron-transferring flavoprotein
FAD + Hexanoyl-CoA <-> FADH2 + trans-Hex-2-enoyl-CoA
FAD + Decanoyl-CoA <-> FADH2 + trans-Dec-2-enoyl-CoA
Decanoyl-CoA + Acceptor <-> trans-Dec-2-enoyl-CoA + Reduced acceptor
Hexanoyl-CoA + Acceptor <-> trans-Hex-2-enoyl-CoA + Reduced acceptor
Octanoyl-CoA + Acceptor <-> trans-Oct-2-enoyl-CoA + Reduced acceptor
Ferricenium hexafluorophosphate + [4-(Dimethylamino)phenyl]propionyl-CoA <-> 4-(Dimethylamino)cinnamoyl-CoA + Ferrocene + Hexafluorophosphate
3-Indolepropionyl-CoA + Ferricenium hexafluorophosphate <-> 3-Indolacryloyl-CoA + Ferrocene + Hexafluorophosphate
Acceptor + cis-Dec-6-enoyl-CoA <-> Reduced acceptor + trans,cis-2,6-Decadienoyl-CoA
Acceptor + cis-Dec-5-enoyl-CoA <-> Reduced acceptor + trans,cis-2,5-Decadienoyl-CoA
Acceptor + cis-Dec-4-enoyl-CoA <-> Reduced acceptor + trans,cis-2,4-Decadienoyl-CoA
Acceptor + cis,cis-4,7-Decadienoyl-CoA <-> Reduced acceptor + trans,cis,cis-2,4,7-Decatrienoyl-CoA
Acceptor + 4-Decynoyl-CoA <-> Reduced acceptor + trans-2-ene-4-Decynoyl-CoA
Acceptor + Glutaramyl-CoA <-> Reduced acceptor + 5-Amino-5-oxopent-2-enoate
Acceptor + Methylglutaryl-CoA <-> Reduced acceptor + 2,3-Dehydromethylglutaryl-CoA
FAD + Pentanoyl-CoA <-> FADH2 + trans-Pent-2-enoyl-CoA
3-Indolepropionyl-CoA + Ferricenium hexafluorophosphate <-> Indoleacryloyl-CoA + Ferrocene + Hexafluorophosphate
O2 + 3-Indolepropionyl-CoA <-> H2O2 + Indoleacryloyl-CoA
Butanoyl-CoA + Ferricenium hexafluorophosphate <-> Crotonoyl-CoA + Ferrocene + Hexafluorophosphate
Decanoyl-CoA + Ferricenium hexafluorophosphate <-> trans-Dec-2-enoyl-CoA + Ferrocene + Hexafluorophosphate
Furylpropionyl-CoA + Ferricenium hexafluorophosphate <-> Furylacryloyl-CoA + Ferrocene + Hexafluorophosphate
Hexanoyl-CoA + Ferricenium hexafluorophosphate <-> trans-Hex-2-enoyl-CoA + Ferrocene + Hexafluorophosphate
Octanoyl-CoA + Ferricenium hexafluorophosphate <-> trans-Oct-2-enoyl-CoA + Ferrocene + Hexafluorophosphate
Acceptor + Pentanoyl-CoA <-> Reduced acceptor + trans-Pent-2-enoyl-CoA
Acceptor + 5-Hexenoyl-CoA <-> Reduced acceptor + Hexa-2,5-dienoyl-CoA
Acceptor + 4-Nitrobutyryl-CoA <-> Reduced acceptor + 4-Nitronate-but-2-enoyl-CoA
Acceptor + 3-Indolepropionyl-CoA <-> Reduced acceptor + 2,3-Dehydroacyl-CoA
Acceptor + Furylpropionyl-CoA <-> Reduced acceptor + 2,3-Dehydroacyl-CoA
Acceptor + [4-(Dimethylamino)phenyl]propionyl-CoA <-> Reduced acceptor + 2,3-Dehydroacyl-CoA
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
1.3.8.7
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