Enzyme Details

EC Classification

1.4.3.3

Enzyme name
(recommended)

D-amino-acid oxidase

Alternative names

D-amino-acid:oxygen oxidoreductase (deaminating)
ophio-amino-acid oxidase
L-amino acid:O2 oxidoreductase
new yellow enzyme

Classification

Oxidoreductases

Acting on the CH-NH(2) group of donors

With oxygen as acceptor

Catalyses reactions

H2O + O2 + D-Glutamate <-> NH3 + H2O2 + 2-Oxoglutarate

H2O + L-Aspartate + O2 <-> NH3 + H2O2 + Oxaloacetate

H2O + O2 + D-Aspartate <-> NH3 + H2O2 + Oxaloacetate

H2O + Glycine + O2 <-> NH3 + Glyoxylate + H2O2

H2O + O2 + D-Amino acid <-> NH3 + H2O2 + 2-Oxo acid

H2O + O2 + D-Ornithine <-> NH3 + H2O2 + 5-Amino-2-oxopentanoate

O2 + D-Proline <-> H2O2 + 1-Pyrroline-2-carboxylate

H2O + O2 + D-Arginine <-> NH3 + H2O2 + 5-Guanidino-2-oxopentanoate

O2 + cis-4-Hydroxy-D-proline <-> H2O2 + 1-Pyrroline-4-hydroxy-2-carboxylate

H2O + O2 + D-Alanine <-> Pyruvate + NH3 + H2O2

H2O + O2 + alpha-Amino acid <-> NH3 + H2O2 + 2-Oxo acid

H2O + O2 + D-Methionine <-> NH3 + H2O2 + 4-Methylthio-2-oxobutanoate

H2O + O2 + D-Phenylalanine <-> NH3 + H2O2 + Phenylpyruvate

H2O + O2 + D-Proline <-> NH3 + H2O2 + 2-Oxopentanoate

H2O + O2 + D-Valine <-> NH3 + H2O2 + alpha-Ketovaline

H2O + O2 + D-Serine <-> NH3 + H2O2 + 3-Hydroxypyruvate

H2O + O2 + D-Lysine <-> NH3 + H2O2 + 6-Amino-2-oxohexanoate

H2O + O2 + D-Isoleucine <-> NH3 + H2O2 + 3-Methyl-2-oxopentanoate

H2O + O2 + Cephalosporin C <-> NH3 + H2O2 + 7-(5-Carboxyl-5-oxopentanyl)-aminocephalosporinate

H2O + O2 + D-Glutamine <-> NH3 + H2O2 + 2-Oxoglutaramate

H2O + O2 + D-Asparagine <-> NH3 + H2O2 + 2-Oxosuccinamate

H2O + O2 + N-Methyl-D-aspartic acid <-> H2O2 + Oxaloacetate + Methylamine

H2O + O2 + D-Tyrosine <-> NH3 + H2O2 + 3-(4-Hydroxyphenyl)pyruvate

H2O + O2 + D-Leucine <-> NH3 + H2O2 + 4-Methyl-2-oxopentanoate

H2O + O2 + D-Tryptophan <-> NH3 + H2O2 + Indolepyruvate

H2O + O2 + (R)-1-Phenylethylamine <-> NH3 + H2O2 + Acetophenone

H2O + O2 + D-Histidine <-> NH3 + H2O2 + 1H-Imidazol-4-yl(oxo)acetic acid

H2O + O2 + D-Dopa <-> NH3 + H2O2 + 3,4-Dihydroxyphenylpyruvate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.4.3.3

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