Enzyme Details

EC Classification

1.5.1.2

Enzyme name
(recommended)

pyrroline-5-carboxylate reductase

Alternative names

L-proline:NAD(P)+ 5-oxidoreductase
proline oxidase
L-proline oxidase
1-pyrroline-5-carboxylate reductase
NADPH-L-Delta1-pyrroline carboxylic acid reductase
L-proline-NAD(P)+ 5-oxidoreductase

Classification

Oxidoreductases

Acting on the CH-NH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + L-Proline <-> NADH + H+ + (S)-1-Pyrroline-5-carboxylate

L-Proline + NADP+ <-> H+ + NADPH + (S)-1-Pyrroline-5-carboxylate

NAD+ + trans-4-Hydroxy-L-proline <-> NADH + H+ + L-1-Pyrroline-3-hydroxy-5-carboxylate

NADP+ + trans-4-Hydroxy-L-proline <-> H+ + NADPH + L-1-Pyrroline-3-hydroxy-5-carboxylate

NAD+ + Thioproline <-> NADH + H+ + 1-Thiopyrroline-5-carboxylate

NADP+ + Thioproline <-> H+ + NADPH + 1-Thiopyrroline-5-carboxylate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.5.1.2