Enzyme Details

EC Classification

1.5.1.20

Enzyme name
(recommended)

methylenetetrahydrofolate reductase [NAD(P)H]

Alternative names

5-methyltetrahydrofolate:NAD(P)+ oxidoreductase
methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase
5,10-methylenetetrahydrofolate reductase (NADPH)
5,10-methylenetetrahydrofolic acid reductase
5,10-CH2-H4folate reductase
methylenetetrahydrofolate reductase (NADPH2)
5-methyltetrahydrofolate:NAD+ oxidoreductase
5-methyltetrahydrofolate:NAD+ oxidoreductase
methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase
5,10-methylenetetrahydrofolate reductase
methylenetetrahydrofolate reductase
N5,10-methylenetetrahydrofolate reductase
5,10-methylenetetrahydropteroylglutamate reductase
N5,N10-methylenetetrahydrofolate reductase
methylenetetrahydrofolic acid reductase
5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect)
5,10-methylenetetrahydrofolate reductase (FADH2)
MetF
methylenetetrahydrofolate reductase (NADPH)
5-methyltetrahydrofolate:NADP+ oxidoreductase

Classification

Oxidoreductases

Acting on the CH-NH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

5,10-Methylenetetrahydrofolate + FADH2 <-> FAD + 5-Methyltetrahydrofolate

NADP+ + 5-Methyltetrahydrofolate <-> H+ + NADPH + 5,10-Methylenetetrahydrofolate

5-Methyltetrahydrofolate + Menadione <-> 5,10-Methylenetetrahydrofolate + Menadiol

H+ + NADPH + Menadione <-> NADP+ + Menadiol

NAD+ + 5-Methyltetrahydrofolate <-> NADH + H+ + 5,10-Methylenetetrahydrofolate

NADH + H+ + Menadione <-> NAD+ + Menadiol

NADH + oxidized MTHFR <-> NAD+ + reduced MTHFR

5,10-Methylenetetrahydrofolate + reduced MTHFR <-> 5-Methyltetrahydrofolate + oxidized MTHFR

Menadione + reduced MTHFR <-> Menadiol + oxidized MTHFR

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.5.1.20