Enzyme Details

EC Classification

1.8.1.14

Enzyme name
(recommended)

CoA-disulfide reductase

Alternative names

CoA:NAD(P)+ oxidoreductase
CoA-disulfide reductase (NADH2)
NADH2:CoA-disulfide oxidoreductase
CoA:NAD+ oxidoreductase
CoADR
coenzyme A disulfide reductase

Classification

Oxidoreductases

Acting on a sulfur group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + 2 Coenzyme A <-> NADH + H+ + CoA-disulfide

NADP+ + 2 Coenzyme A <-> H+ + NADPH + CoA-disulfide

H+ + NADPH + 3'-Dephospho-CoA-disulfide <-> NADP+ + 2 3'-Dephospho-CoA

H+ + NADPH + 4,4'-Diphosphopantethine <-> NADP+ + 2 4'-Phosphopantetheine

NADP+ + Coenzyme A + Reduced glutathione <-> H+ + NADPH + CoA-glutathione

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.8.1.14