Enzyme Details

EC Classification

1.8.1.9

Enzyme name
(recommended)

thioredoxin-disulfide reductase

Alternative names

thioredoxin:NADP+ oxidoreductase
NADP-thioredoxin reductase
NADPH-thioredoxin reductase
thioredoxin reductase (NADPH)
NADPH2:oxidized thioredoxin oxidoreductase

Classification

Oxidoreductases

Acting on a sulfur group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NADP+ + Reduced thioredoxin <-> H+ + NADPH + Oxidized thioredoxin

H+ + NADPH + 1,4-Benzoquinone <-> NADP+ + Hydroquinone

H+ + NADPH + Menadione <-> NADP+ + Menadiol

NADPH + Methyl-1,4-benzoquinone <-> NADP+ + Methylhydroquinone

H+ + NADPH + Dithionitrobenzoic acid <-> NADP+ + 2 3-Carboxyl-4-nitrothiophenolate

H+ + NADPH + Methyl methanethiolsulfonate <-> NADP+ + Reduced methyl methanethiolsulfonate

2 H+ + 2 NADPH + 2,3-Dichloro-1,4-naphthoquinone <-> 2 NADP+ + Dichloro-hydronaphthoquinone

2 H+ + 2 NADPH + 2,5-Diaziridinyl-1,4-benzoquinone <-> 2 NADP+ + 2,5-Diaziridinyl-hydroquinone

2 H+ + 2 NADPH + 2,5-Dimethyl-3,6-diaziridinyl-1,4-benzoquinone <-> 2 NADP+ + 2,5-Dimethyl-3,6-diaziridinyl-hydroquinone

2 H+ + 2 NADPH + 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone <-> 2 NADP+ + 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-hydroquinone

2 H+ + 2 NADPH + 2-Hydroxy-1,4-naphthoquinone <-> 2 NADP+ + 2-Hydroxy-hydronaphthoquinone

H+ + NADPH + 5-Hydroxy-1,4-naphthoquinone <-> NADP+ + 1,4,5-Naphthalenetriol

2 H+ + 2 NADPH + 2-Methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinone <-> 2 NADP+ + 2-Methyl-3-glutathionyl-5-hydroxy-hydronaphthoquinone

2 H+ + 2 NADPH + 9,10-Phenanthroquinone <-> 2 NADP+ + trans-9(S),10(S)-Dihydrodiolphenanthrene

2 H+ + 2 NADPH + Duroquinone <-> 2 NADP+ + Tetramethyl-hydroquinone

2 H+ + 2 NADPH + 2,5-Dimethyl-1,4-benzoquinone <-> 2 NADP+ + 2,5-Dichlorohydroquinone

2 H+ + 2 NADPH + Naphthazarin <-> 2 NADP+ + 5,8-Dihydroxy-hydronaphthoquinone

2 H+ + 2 NADPH + 1,4-Naphthoquinone <-> 2 NADP+ + Hydronaphthoquinone

2 H+ + 2 NADPH + 2-Methyl-5-hydroxy-1,4-naphthoquinone <-> 2 NADP+ + 2-Methyl-5-hydroxy-hydronaphthoquinone

H+ + NADPH + Oxidized glutaredoxin <-> NADP+ + Reduced glutaredoxin

H+ + NADPH + 5,5'-Dithiobis(2-nitrobenzoic acid) <-> NADP+ + 2 2-Nitro-5-thiobenzoic acid

H+ + NADPH + Hydroxyethyl disulfide <-> NADP+ + 2 2-Mercaptoethanol

NADH + H+ + 5,5'-Dithiobis(2-nitrobenzoic acid) <-> NAD+ + 2 2-Nitro-5-thiobenzoic acid

Reduced thioredoxin + Insulin <-> Oxidized thioredoxin + Insulin dithiol

NADH + H+ + Oxidized thioredoxin <-> NAD+ + Reduced thioredoxin

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.8.1.9