Enzyme Details

EC Classification

2.1.1.49

Enzyme name
(recommended)

amine N-methyltransferase

Alternative names

S-adenosyl-L-methionine:amine N-methyltransferase
nicotine N-methyltransferase
tryptamine N-methyltransferase
arylamine N-methyltransferase
tryptamine methyltransferase

Classification

Transferases

Transferring one-carbon groups

Methyltransferases

Catalyses reactions

S-Adenosyl-L-methionine + Tryptamine <-> S-Adenosyl-L-homocysteine + N-Methyltryptamine

S-Adenosyl-L-methionine + Amine <-> S-Adenosyl-L-homocysteine + Methylated amine

S-Adenosyl-L-methionine + Serotonin <-> S-Adenosyl-L-homocysteine + N-Methylserotonin

S-Adenosyl-L-methionine + Desipramine <-> S-Adenosyl-L-homocysteine + Imipramine

S-Adenosyl-L-methionine + Pyrazole <-> S-Adenosyl-L-homocysteine + 1-Methylpyrazole

S-Adenosyl-L-methionine + 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline <-> S-Adenosyl-L-homocysteine + N-Methyl-7,8-dichloro-1,2,3,4-tetrahydroisoquinoline

S-Adenosyl-L-methionine + Imidazole <-> S-Adenosyl-L-homocysteine + N-Methylimidazole

S-Adenosyl-L-methionine + Aniline <-> S-Adenosyl-L-homocysteine + N-Methylaniline

S-Adenosyl-L-methionine + Norharmane <-> S-Adenosyl-L-homocysteine + N-Methylnorharmane

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.1.1.49