Enzyme Details

 EC Classification 2.1.2.11
 Enzyme name
(recommended)
3-methyl-2-oxobutanoate hydroxymethyltransferase
 Alternative names 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase
alpha-ketoisovalerate hydroxymethyltransferase
dehydropantoate hydroxymethyltransferase
ketopantoate hydroxymethyltransferase
oxopantoate hydroxymethyltransferase
5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase
 Classification
Transferases
Transferring one-carbon groups
Hydroxymethyl-, formyl- and related transferases
 Catalyses reactions
H2O + 5,10-Methylenetetrahydrofolate + alpha-Ketovaline <-> 5,6,7,8-Tetrahydrofolate + 2-Dehydropantoate
2-Dehydropantoate + Tetrahydrofolyl-[Glu](2) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](2)
2-Dehydropantoate + Tetrahydrofolyl-[Glu](3) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](3)
2-Dehydropantoate + Tetrahydrofolyl-[Glu](4) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](4)
2-Dehydropantoate + Tetrahydrofolyl-[Glu](5) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](5)
2-Dehydropantoate + Tetrahydrofolyl-[Glu](6) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](6)
2-Dehydropantoate + Tetrahydrofolyl-[Glu](7) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](7)
H2O + 5,10-Methylenetetrahydrofolate + 2-Oxobutyrate <-> 5,6,7,8-Tetrahydrofolate + 4-Hydroxy-3-methyl-2-oxobutanoic acid
H2O + 5,10-Methylenetetrahydrofolate + 2-Oxopentanoate <-> 5,6,7,8-Tetrahydrofolate + 3-Hydroxymethyl-2-oxopentanoic acid
H2O + 5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxopentanoate <-> 5,6,7,8-Tetrahydrofolate + 3-(Hydroxymethyl)-3-methyl-2-oxopentanoic acid
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 2.1.2.11



© HITS gGmbH