EC Classification |
2.1.2.11
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Enzyme name (recommended) |
3-methyl-2-oxobutanoate hydroxymethyltransferase |
Alternative names |
5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase
alpha-ketoisovalerate hydroxymethyltransferase
dehydropantoate hydroxymethyltransferase
ketopantoate hydroxymethyltransferase
oxopantoate hydroxymethyltransferase
5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase
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Classification |
Transferases |
Transferring one-carbon groups |
Hydroxymethyl-, formyl- and related transferases |
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Catalyses reactions
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H2O + 5,10-Methylenetetrahydrofolate + alpha-Ketovaline <-> 5,6,7,8-Tetrahydrofolate + 2-Dehydropantoate |
2-Dehydropantoate + Tetrahydrofolyl-[Glu](2) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](2) |
2-Dehydropantoate + Tetrahydrofolyl-[Glu](3) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](3) |
2-Dehydropantoate + Tetrahydrofolyl-[Glu](4) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](4) |
2-Dehydropantoate + Tetrahydrofolyl-[Glu](5) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](5) |
2-Dehydropantoate + Tetrahydrofolyl-[Glu](6) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](6) |
2-Dehydropantoate + Tetrahydrofolyl-[Glu](7) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](7) |
H2O + 5,10-Methylenetetrahydrofolate + 2-Oxobutyrate <-> 5,6,7,8-Tetrahydrofolate + 4-Hydroxy-3-methyl-2-oxobutanoic acid |
H2O + 5,10-Methylenetetrahydrofolate + 2-Oxopentanoate <-> 5,6,7,8-Tetrahydrofolate + 3-Hydroxymethyl-2-oxopentanoic acid |
H2O + 5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxopentanoate <-> 5,6,7,8-Tetrahydrofolate + 3-(Hydroxymethyl)-3-methyl-2-oxopentanoic acid |
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External links
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Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
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View all entries for EC Class:
2.1.2.11
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