Enzyme Details
EC Classification
2.3.1.286
Enzyme name
(recommended)
protein acetyllysine N-acetyltransferase
Alternative names
protein lysine deacetylase
NAD+-dependent protein deacetylase
Classification
Transferases
Acyltransferases
Acyltransferases
Catalyses reactions
NAD+ + H2O + acetylated Acetyl-CoA synthetase <-> Nicotinamide + Acetyl-CoA synthetase + O-Acetyl-ADP-ribose
NAD+ + Methanol + acetylated Histone H3-peptide <-> Nicotinamide + acetylated Histone H3-peptide + beta-1-O-Methyl-adenosine diphosphoribose
NAD+ + H2O + acetylated Histone H3-peptide <-> Nicotinamide + deacetylated Histone H3-peptide + O-Acetyl-ADP-ribose
NAD+ + Nicotinamide + acetylated Histone H3-peptide <-> NAD+ + Nicotinamide + acetylated Histone H3-peptide
NAD+ + H2O + acetylated Histone H3-peptide <-> Nicotinamide + ADPribose + acetylated Histone H3-peptide
NAD+ + Methanol <-> Nicotinamide + alpha-1-O-Methyl-adenosine diphosphoribose
NAD+ + Thionicotinamide + acetylated Histone H3-peptide <-> Nicotinamide + thio-NAD+ + acetylated Histone H3-peptide
NAD+ + H2O + acetylated Histone H4-peptide <-> Nicotinamide + deacetylated Histone H4-peptide + O-Acetyl-ADP-ribose
NAD+ + H2O + acetylated Histone H4-peptide <-> Nicotinamide + ADPribose + acetylated Histone H4-peptide
NAD+ + H2O + acetylated p300-peptide <-> Nicotinamide + deacetylated p300-peptide + O-Acetyl-ADP-ribose
NAD+ + Nicotinamide + acetylated p300-peptide <-> NAD+ + Nicotinamide + acetylated p300-peptide
NAD+ + H2O + acetylated p300-peptide <-> Nicotinamide + ADPribose + acetylated p300-peptide
NAD+ + H2O <-> Nicotinamide + ADPribose
NAD+ + H2O + N6-Acetyl-L-lysyl peptide <-> Nicotinamide + O-Acetyl-ADP-ribose + L-lysyl peptide
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
2.3.1.286
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